Reversal of temperature responses to methylone mediated through bi-directional fecal microbiota transplantation between hyperthermic tolerant and naïve rats
Sign Up to like & getrecommendations! Published in 2022 at "Temperature"
DOI: 10.1080/23328940.2022.2069965
Abstract: ABSTRACT The synthetic cathinone (“bath salt”) methylone induces a hyperthermia response and with chronic administration tolerance to this hyperthermia has been reported. The microbiome-gut-brain axis has been implicated in multiple bodily systems and pathologies, and… read more here.
Keywords: microbiota transplantation; methylone; fecal microbiota; transplantation ... See more keywords
Pharmacological effects of methylone and MDMA in humans
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DOI: 10.3389/fphar.2023.1122861
Abstract: Methylone is one of the most common synthetic cathinones popularized as a substitute for 3,4-methylenedioxymethamphetamine (MDMA, midomafetamine) owing to its similar effects among users. Both psychostimulants exhibit similar chemistry (i.e., methylone is a β-keto analog… read more here.
Keywords: effects methylone; pharmacology; methylone; mdma ... See more keywords
Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.1041277
Abstract: Introduction Selective serotonin reuptake inhibitor (SSRI) antidepressants represent first-line pharmacological treatment for a variety of neuropsychiatric illnesses, including major depressive disorder (MDD), anxiety, and post-traumatic stress disorder (PTSD), which show high rates of comorbidity. SSRIs… read more here.
Keywords: rapid acting; acting entactogen; methylone; antidepressant like ... See more keywords
Methylone and MDMA Pharmacokinetics Following Controlled Administration in Humans
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DOI: 10.3390/ijms232314636
Abstract: The aim of this study is to define, for the first time, human methylone and HMMC plasma pharmacokinetics following controlled administration of 50–200 mg methylone to 12 male volunteers. A new LC-MS/MS method was validated… read more here.
Keywords: controlled administration; methylone; following controlled; methylone mdma ... See more keywords
Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans
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DOI: 10.3390/ijms24087395
Abstract: The aim of this study was to determine the excretion of methylone and its metabolites in sweat following the ingestion of increasing controlled doses of 50, 100, 150 and 200 mg of methylone to twelve… read more here.
Keywords: sweat testing; methylone metabolites; detection methylone; methylone ... See more keywords