Evaluation of Methylphenidate Safety and Maximum-Dose Titration Rationale in Attention-Deficit/Hyperactivity Disorder: A Meta-analysis.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2019.0905
Abstract: Importance Evidence on the titration of stimulant medications for attention-deficit/hyperactivity disorder (ADHD) is lacking. However, this lack of evidence has not prevented medication guidelines from specifying apparently arbitrary dose limitations, which could discourage clinicians from… read more here.
Keywords: titration; dose titration; disorder; maximum dose ... See more keywords
Abstinence following intermittent methylphenidate exposure dose‐dependently modifies brain glucose metabolism in the rat brain
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22243
Abstract: Methylphenidate (MP) is a psychostimulant chronically prescribed for the treatment of attention deficit hyperactivity disorder (ADHD). Additionally, MP users may take breaks from using the medication during “drug holidays,” which may include short‐term or long‐term… read more here.
Keywords: brain glucose; abstinence; brain; glucose metabolism ... See more keywords
Treatment effect of methylphenidate on intrinsic functional brain network in medication-naïve ADHD children: A multivariate analysis
Sign Up to like & getrecommendations! Published in 2017 at "Brain Imaging and Behavior"
DOI: 10.1007/s11682-017-9713-z
Abstract: Methylphenidate is a first-line therapeutic option for treating attention-deficit/hyperactivity disorder (ADHD); however, elicited changes on resting-state functional networks (RSFNs) are not well understood. This study investigated the treatment effect of methylphenidate using a variety of… read more here.
Keywords: network; analysis; treatment; methylphenidate ... See more keywords
Effect of Chronic Methylphenidate Treatment in a Female Experimental Model of Parkinsonism.
Sign Up to like & getrecommendations! Published in 2021 at "Neurotoxicity research"
DOI: 10.1007/s12640-021-00347-9
Abstract: Methylphenidate (MPH) is the most commonly prescribed drug for the treatment of ADHD in males and females. However, a majority of previous studies investigated the effect of MPH in only males, and little is known… read more here.
Keywords: mph; treatment; exposure; effect ... See more keywords
Chronic treatment and abstinence from methylphenidate exposure dose-dependently changes glucose metabolism in the rat brain
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research"
DOI: 10.1016/j.brainres.2022.147799
Abstract: Methylphenidate (MP) is extensively prescribed for attention deficit hyperactivity disorder (ADHD). While MP is effective in ameliorating symptoms of ADHD, MP is also used illicitly among healthy subjects without ADHD for cognitive-enhancing purposes. The deleterious… read more here.
Keywords: methylphenidate; treatment; glucose metabolism; abstinence ... See more keywords
Catalytic hydrolysis mechanism of aminocarboxylester substrate by human carboxylesterase 1: A theoretical study on methylphenidate hydrolysis
Sign Up to like & getrecommendations! Published in 2021 at "Computational and Theoretical Chemistry"
DOI: 10.1016/j.comptc.2021.113198
Abstract: Abstract Human carboxylesterase 1 (hCES1) is an important carboxylesterase responsible for the hydrolysis of various esters and amides, and plays very important roles in drug metabolism and pharmacokinetics. In this study, we investigated hCES1-catalyzed hydrolysis… read more here.
Keywords: human carboxylesterase; hydrolysis; carboxylesterase; methylphenidate ... See more keywords
The impact of methylphenidate and its enantiomers on dopamine synthesis and metabolism in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2017.07.002
Abstract: Methylphenidate (MPH), a psychostimulant, is an effective first-line treatment for the symptoms associated with Attention-Deficit/Hyperactivity Disorder (ADHD). Although most MPH formulations are composed of the racemic 1:1 mixture of the two enantiomers (d- and l-threo),… read more here.
Keywords: mph; racemic mixture; methylphenidate; threo mph ... See more keywords
The effect of long-term use of methylphenidate on cardiac autonomic functions and ventricular arrhythmogenesis: a prospective case-control study.
Sign Up to like & getrecommendations! Published in 2023 at "Cardiology in the young"
DOI: 10.1017/s1047951123001038
Abstract: OBJECTIVE We aimed to assess cardiac autonomic balance with heart rate variability by using 24-hour Holter electrocardiography and also to assess susceptibility to ventricular arrhythmias by using microvolt T wave alternance in children with attention… read more here.
Keywords: cardiac autonomic; autonomic functions; microvolt wave; methylphenidate ... See more keywords
Integrative genomic analysis of methylphenidate response in attention-deficit/hyperactivity disorder
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20194-7
Abstract: Methylphenidate (MPH) is the most frequently used pharmacological treatment in children with attention-deficit/hyperactivity disorder (ADHD). However, a considerable interindividual variability exists in clinical outcome. Thus, we performed a genome-wide association study of MPH efficacy in… read more here.
Keywords: attention deficit; methylphenidate; deficit hyperactivity; hyperactivity disorder ... See more keywords
Effects of Discontinuing Methylphenidate on Strengths and Difficulties, Quality of Life and Parenting Stress.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of child and adolescent psychopharmacology"
DOI: 10.1089/cap.2019.0147
Abstract: Objectives: To study the effects of discontinuation of long-term methylphenidate use on secondary outcome measures of strengths and difficulties, quality of life (QoL), and parenting stress. Methods: Ninety-four children and adolescents aged 8 to 18… read more here.
Keywords: parenting stress; strengths difficulties; methylphenidate; quality life ... See more keywords
QOL-23. ASSESSING THE IMPACT OF METHYLPHENIDATE ON LATE COGNITIVE EFFECTS IN PAEDIATRIC BRAIN TUMOUR SURVIVORS: A SERVICE-BASED EVALUATION
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.685
Abstract: Abstract OBJECTIVE One of the most disabling side effects of treatment in survivors of brain tumours is the resultant reduction in level of processing speed and attention. This study aimed to evaluate intellectual and psychological… read more here.
Keywords: qol assessing; brain tumour; attention; methylphenidate ... See more keywords