Synthesis of 9‐(6‐Deoxy‐α‐L‐Talofuranosyl)‐6‐Methylpurine and 9‐(6‐Deoxy‐β‐D‐Allofuranosyl)‐6‐Methylpurine Nucleosides
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DOI: 10.1002/cpnc.105
Abstract: 6‐Methylpurine (MeP) is a cytotoxic adenine analog that does not exhibit selectivity when administered systemically and could be very useful in a gene therapy approach to cancer treatment involving Escherichia coli purine nucleoside phosphorylase (PNP).… read more here.
Keywords: deoxy allofuranosyl; methylpurine; deoxy; talofuranosyl methylpurine ... See more keywords
Development of an Effective 6-Methylpurine Counterselection Marker for Genetic Manipulation in Thermococcus barophilus
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DOI: 10.3390/genes9020077
Abstract: A gene disruption system for Thermococcus barophilus was developed using simvastatin (HMG-CoA reductase encoding gene) for positive selection and 5-Fluoroorotic acid (5-FOA), a pyrF gene for negative selection. Multiple gene mutants were constructed with this… read more here.
Keywords: barophilus; methylpurine; marker; gene ... See more keywords