Design, synthesis and antitumor evaluation of novel 5-methylpyrazolo[1,5-a]pyrimidine derivatives as potential c-Met inhibitors.
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DOI: 10.1016/j.bioorg.2020.104356
Abstract: A series of novel 5-methylpyrazolo[1,5-a]pyrimidine derivatives (10a-10x) were designed, synthesized, and evaluated for their in vitro inhibitory activities against c-Met kinase and antiproliferative activities against the SH-SY5Y, MDA-MB-231, A549, and HepG2 cell lines. Most of… read more here.
Keywords: methylpyrazolo pyrimidine; novel methylpyrazolo; met inhibitors; pyrimidine derivatives ... See more keywords