Synthesis of N-methylpyridine-chlorofuranformamide analogs as novel OPG up-regulators and inhibitors of RANKL-induced osteoclastogenesis.
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DOI: 10.1016/j.bioorg.2021.105361
Abstract: The OPG/RANKL/RANK pathway is a promising target for the design of therapeutic agents used in the treatment of osteoporosis. E09241 with an N-methylpyridine-chlorofuranformamide structural skeleton was previously identified to decrease bone loss and thus protect… read more here.
Keywords: opg; methylpyridine chlorofuranformamide; induced osteoclastogenesis; rankl induced ... See more keywords