6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
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DOI: 10.1021/acs.jmedchem.8b01726
Abstract: Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell death PD-L1/PD-1 pathway. In the preceding manuscript, we described the… read more here.
Keywords: shp2; potent selective; amino methylpyrimidinones; methylpyrimidinones potent ... See more keywords