I2-DMSO Promoted Deaminative Coupling Reactions of Glycine Esters: Access to 5-(Methylthio)pyridazin-3(2H)-ones.
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DOI: 10.1021/acs.orglett.3c00306
Abstract: An unprecedented, one-step strategy for the synthesis of 5-(methylthio)pyridazin-3(2H)-one derivatives has been developed through iodine triggered deaminative coupling of glycine esters with methyl ketones and hydrazine hydrate in DMSO. These transformations in the absence of… read more here.
Keywords: dmso promoted; methylthio pyridazin; glycine esters; promoted deaminative ... See more keywords