Protective effect of histone methyltransferase NSD3 on ISO‐induced cardiac hypertrophy
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13515
Abstract: Nuclear receptor‐binding SET domain 3 (NSD3) is a lysine methyltransferase that plays important roles in multiple biological activities; however; its potential roles in the cardiovascular system remain unknown. In this study, we found that NSD3… read more here.
Keywords: cardiomyocyte hypertrophy; protective effect; methyltransferase; hypertrophy ... See more keywords
Histone-lysine N-methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc-driven liver cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13417
Abstract: Hepatocellular carcinoma (HCC) is the third deadliest and sixth most common cancer in the world. Histone-lysine N-methyltransferase EHMT2 (also known as G9a) is a histone methyltransferase frequently overexpressed in many cancer types, including HCC. We… read more here.
Keywords: driven liver; histone; g9a; myc driven ... See more keywords
Triple combination targeting methyltransferase, BCL‐2, and PD‐1 facilitates antileukemia responses in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34566
Abstract: A recent breakthrough therapy combining the BCL‐2 inhibitor venetoclax with hypomethylating agents (HMAs) targeting DNA methyltransferase has improved outcomes for patients with acute myeloid leukemia (AML), but the responses and long‐term survival in older/unfit patients… read more here.
Keywords: myeloid leukemia; triple combination; acute myeloid; methyltransferase ... See more keywords
Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31642
Abstract: Cholangiocarcinoma (CCA) is a devastating disease often detected at advanced stages when surgery cannot be performed. Conventional and targeted systemic therapies perform poorly, and therefore effective drugs are urgently needed. Different epigenetic modifications occur in… read more here.
Keywords: dual targeting; methyltransferase; cholangiocarcinoma; dna methyltransferase ... See more keywords
Abrogation of myofibroblast activities in metastasis and fibrosis by methyltransferase inhibition
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32376
Abstract: Myofibroblasts are a population of highly contractile fibroblasts that express and require the activity of the transcription factor Snail1. Cancer‐associated fibroblasts (CAFs) correlate with low survival of cancer patients when present in the stroma of… read more here.
Keywords: fibrosis; snail1; methyltransferase; myofibroblast ... See more keywords
Molecular cloning and functional analysis of a biphenyl phytoalexin-specific O-methyltransferase from apple cell suspension cultures
Sign Up to like & getrecommendations! Published in 2018 at "Planta"
DOI: 10.1007/s00425-018-3031-6
Abstract: Main conclusionThis manuscript describes the cloning and functional characterization of a biphenyl phytoalexin biosynthetic gene, 3,5-dihydroxybiphenyl O-methyltransferase from elicitor-treated cell cultures of scab resistant apple cultivar ‘Florina’.Apples belong to the subtribe Malinae of the Rosaceae… read more here.
Keywords: methyltransferase; biphenyl; cloning functional; apple ... See more keywords
Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor
Sign Up to like & getrecommendations! Published in 2017 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-017-9753-8
Abstract: NSD3 is a histone H3 methyltransferase that plays an important role in chromatin biology. A construct containing the methyltransferase domain encompassing residues Q1049-K1299 of human NSD3 was obtained and biochemical activity was demonstrated using histone… read more here.
Keywords: backbone resonance; resonance assignments; methyltransferase; nsd3 ... See more keywords
Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase
Sign Up to like & getrecommendations! Published in 2019 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-018-9849-9
Abstract: Bacterial tRNA (guanine37-N1)-methyltransferase (TrmD) is an important antibacterial target due to its essential role in translation. TrmD has two domains connected with a flexible linker. The N-terminal domain (NTD) of TrmD contains the S-adenosyl-l-methionine (SAM)… read more here.
Keywords: backbone resonance; methyltransferase; trna; resonance assignment ... See more keywords
Fluorescent copper nanoclusters as a nano-dye for DNA methyltransferase activity analysis and inhibitor screening.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2018.08.011
Abstract: Fluorescent copper nanoslusters (CuNCs) as a new class of fluorophores have attracted more and more attention due to their ease of synthesis, excellent optical properties, and low cost. In this study, a novel label-free fluorescent… read more here.
Keywords: dam mtase; fluorescent copper; methyltransferase; copper nanoclusters ... See more keywords
Detection of DNA methyltransferase activity using template-free DNA polymerization amplification based on aggregation-induced emission.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2019.113532
Abstract: A sensitive and selective fluorescence assay for DNA methyltransferase (MTase) activity detection was designed based on aggregation-induced emission (AIE) and target initiated template-free DNA polymerization. Quaternized tetraphenylethene salt was synthesized as the AIE probe, which… read more here.
Keywords: detection; dna; methyltransferase; mtase ... See more keywords
Interaction of silver nanoparticles with catechol O-methyltransferase: Spectroscopic and simulation analyses
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101013
Abstract: Catechol O-methyltransferase, an enzyme involved in the metabolism of catechol containing compounds, catalyzes the transfer of a methyl group between S-adenosylmethionine and the hydroxyl groups of the catechol. Furthermore it is considered a potential drug… read more here.
Keywords: interaction silver; catechol methyltransferase; methyltransferase; spectroscopy ... See more keywords