C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels
Sign Up to like & getrecommendations! Published in 2019 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-019-0247-3
Abstract: The polycomb repressive complex 2 (PRC2) catalyzes the methylation of histone H3 on lysine 27 (H3K27) to generate trimethyl-H3K27 (H3K27me3) marks, thereby leading to a repressive chromatin state that inhibits gene expression. C10ORF12 was recently… read more here.
Keywords: histone methyltransferase; h3k27me3 levels; methyltransferase activity; h3k27me3 ... See more keywords
Identification of FAM173B as a protein methyltransferase promoting chronic pain
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Biology"
DOI: 10.1371/journal.pbio.2003452
Abstract: Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain.… read more here.
Keywords: methyltransferase activity; methyltransferase; fam173b; neurobiology ... See more keywords
Primitive Erythropoiesis in the Mouse is Independent of DOT1L Methyltransferase Activity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.813503
Abstract: DOT1-like (DOT1L) histone methyltransferase is essential for mammalian erythropoiesis. Loss of DOT1L in knockout (Dot1l-KO) mouse embryos resulted in lethal anemia at midgestational age. The only recognized molecular function of DOT1L is its methylation of… read more here.
Keywords: dot1l methyltransferase; dot1l; methyltransferase; methyltransferase activity ... See more keywords
Pharmacological Modulation of Flavivirus Methyltransferase Activity of Dengue Virus (DEV)
Sign Up to like & getrecommendations! Published in 2019 at "Indian Journal of Pharmaceutical Education and Research"
DOI: 10.5530/ijper.53.3s.116
Abstract: Background: The occurrence of dengue fever plagues has expanded significantly in the course of the most recent couple of decades. Be that as it may, no immunization or antiviral treatments are accessible. In this manner,… read more here.
Keywords: methyltransferase; dengue virus; methyltransferase activity;