Discovery of Inhibitors of DNA Methyltransferase 2, an Epitranscriptomic Modulator and Potential Target for Cancer Treatment.
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DOI: 10.1021/acs.jmedchem.2c00388
Abstract: Selective manipulation of the epitranscriptome could be beneficial for the treatment of cancer and also broaden the understanding of epigenetic inheritance. Inhibitors of the tRNA methyltransferase DNMT2, the enzyme catalyzing the S-adenosylmethionine-dependent methylation of cytidine… read more here.
Keywords: methyltransferase epitranscriptomic; discovery inhibitors; dna methyltransferase; treatment ... See more keywords