Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac121
Abstract: Kabuki syndrome (KS) is frequently caused by loss-of-function mutations in one allele of the H3K4 methyltransferase KMT2D and is associated with problems in neurological, immunological, and skeletal system development. We generated heterozygous KMT2D knock-out and… read more here.
Keywords: cell; stem cell; methyltransferase kmt2d; kmt2d ... See more keywords
Histone Methyltransferase KMT2D Regulates H3K4 Methylation and is Involved in the Pathogenesis of Ovarian Cancer
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DOI: 10.1177/09636897211027521
Abstract: To investigate the function of histone-lysine N-methyltransferase 2D (KMT2D) on the methylation of H3 lysine 4 (H3K4) in the progression of Ovarian cancer (OV). KMT2D, ESR1 and H3K4me expressions in surgical resected tumors and tumor… read more here.
Keywords: kmt2d; h3k4me; methyltransferase kmt2d; ovarian cancer ... See more keywords
Lysine methyltransferase Kmt2d regulates naive CD8+ T cell activation-induced survival
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DOI: 10.3389/fimmu.2022.1095140
Abstract: Lysine specific methyltransferase 2D (Kmt2d) catalyzes the mono-methylation of histone 3 lysine 4 (H3K4me1) and plays a critical role in regulatory T cell generation via modulating Foxp3 gene expression. Here we report a role of… read more here.
Keywords: cell; methyltransferase kmt2d; cd8 cell; activation induced ... See more keywords