Site-specific RNA methylation by a methyltransferase ribozyme
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DOI: 10.1038/s41586-020-2854-z
Abstract: Nearly all classes of coding and non-coding RNA undergo post-transcriptional modification, including RNA methylation. Methylated nucleotides are among the evolutionarily most-conserved features of transfer (t)RNA and ribosomal (r)RNA 1 , 2 . Many contemporary methyltransferases use… read more here.
Keywords: methylation; site specific; ribozyme; rna ... See more keywords
Structure and mechanism of the methyltransferase ribozyme MTR1
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DOI: 10.1038/s41589-022-00976-x
Abstract: RNA-catalyzed RNA methylation was recently shown to be part of the catalytic repertoire of ribozymes. The methyltransferase ribozyme MTR1 catalyzes the site-specific synthesis of 1-methyladenosine (m1A) in RNA, using O6-methylguanine (m6G) as a methyl group… read more here.
Keywords: methyltransferase ribozyme; site; structure; ribozyme mtr1 ... See more keywords
Structure and mechanism of a methyltransferase ribozyme
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DOI: 10.1038/s41589-022-00982-z
Abstract: Known ribozymes in contemporary biology perform a limited range of chemical catalysis, but in vitro selection has generated species that catalyze a broader range of chemistry; yet, there have been few structural and mechanistic studies… read more here.
Keywords: chemistry; methyltransferase ribozyme; structure; biology ... See more keywords