Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development
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DOI: 10.1016/j.isci.2020.100941
Abstract: Summary Repair of DNA double-stranded breaks (DSBs) during lymphocyte development is essential for V(D)J recombination and forms the basis of immunoglobulin variable region diversity. Understanding of this process in lymphogenesis has historically been centered on… read more here.
Keywords: recombination; methyltransferase setd2; development; loss ... See more keywords
Methyltransferase SETD2 inhibits tumor growth and metastasis via STAT1–IL‐8 signaling‐mediated epithelial–mesenchymal transition in lung adenocarcinoma
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DOI: 10.1111/cas.15299
Abstract: Lung adenocarcinoma (LUAD) is a major subtype of non–small‐cell lung cancer, which is the leading cause of cancer death worldwide. The histone H3K36 methyltransferase SETD2 has been reported to be frequently mutated or deleted in… read more here.
Keywords: tumor growth; methyltransferase setd2; lung adenocarcinoma; lung ... See more keywords
Elevated levels of the methyltransferase SETD2 causes transcription and alternative splicing changes resulting in oncogenic phenotypes
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DOI: 10.3389/fcell.2022.945668
Abstract: The methyltransferase SETD2 regulates cryptic transcription, alternative splicing, and the DNA damage response. It is mutated in a variety of cancers and is believed to be a tumor suppressor. Counterintuitively, despite its important role, SETD2… read more here.
Keywords: transcription alternative; alternative splicing; methyltransferase setd2;