Combined inhibition of histone methyltransferases EZH2 and DOT1L is an effective therapy for neuroblastoma
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DOI: 10.1002/cam4.70082
Abstract: The child cancer, neuroblastoma (NB), is characterised by a low incidence of mutations and strong oncogenic embryonal driver signals. Many new targeted epigenetic modifier drugs have failed in human trials as monotherapy. read more here.
Keywords: combined inhibition; ezh2 dot1l; methyltransferases ezh2; inhibition histone ... See more keywords
Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens
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DOI: 10.1128/mbio.01141-17
Abstract: ABSTRACT Epigenetic regulation is based on a network of complexes that modulate the chromatin character and structure of the genome to impact gene expression, cell fate, and development. Thus, epigenetic modulators represent novel therapeutic targets… read more here.
Keywords: viral pathogens; suppress infection; infection; methyltransferases ezh2 ... See more keywords