Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [11C]Metoclopramide in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical research"
DOI: 10.1007/s11095-021-03002-2
Abstract: PURPOSE To investigate the role of cation transporters (OCTs, MATEs) in the renal and hepatic disposition of the radiolabeled antiemetic drug [11C]metoclopramide in mice with PET. METHODS PET was performed in wild-type mice after administration… read more here.
Keywords: 11c metoclopramide; metoclopramide mice; metoclopramide; cation transporters ... See more keywords
Development of a hydrophilic transdermal patch for combined delivery of sumatriptan and metoclopramide in migraine therapy
Sign Up to like & getrecommendations! Published in 2025 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-025-01874-0
Abstract: Migraine, a prevalent neurological disorder, is known to significantly impact patients' quality of life. The effectiveness of oral medications is often hindered by nausea and vomiting, common migraine symptoms. In this study, a transdermal patch… read more here.
Keywords: patch; delivery; sumatriptan; migraine ... See more keywords
The effect of GnRHa with or without dopamine inhibitor on reproductive hormone levels and sperm quality in tench Tinca tinca
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DOI: 10.1016/j.aquaculture.2016.12.023
Abstract: The impact of treatment with mGnRHa, mGnRHa with metoclopramide, and metoclopramide on secretion of luteinizing hormone (LH), testosterone (T) and 11-ketotestosterone (11-KT) and on milt and spermatozoon characteristics was studied in male tench Tinca tinca.… read more here.
Keywords: tinca; tinca tinca; treatment; metoclopramide ... See more keywords
Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents
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DOI: 10.1111/cts.12803
Abstract: Metoclopramide is commonly used for gastroesophageal reflux. The aims of the present study were to develop a pediatric population pharmacokinetic (PopPK) model, which was applied to simulate the metoclopramide exposure following dosing used in clinical… read more here.
Keywords: virtual patients; metoclopramide; model; population pharmacokinetics ... See more keywords
Comparing the Effect of Neostigmine and Metoclopramide on Gastric Residual Volume of Mechanically Ventilated Patients in Intensive Care Unit: A Double-Blind Randomized Clinical Trial
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DOI: 10.1155/2021/5550653
Abstract: Introduction The gastric residual volume (GRV) monitoring in patients with mechanical ventilation (MV) is a common and important challenge. The purpose of this study was to compare the effect of neostigmine and metoclopramide on GRV… read more here.
Keywords: gastric residual; metoclopramide; effect neostigmine; effect ... See more keywords
Metoclopramide to Prevent Pneumonia in Patients With Stroke and a Nasogastric Tube: Data From the PRECIOUS Trial
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DOI: 10.1161/strokeaha.124.047582
Abstract: BACKGROUND: A randomized trial suggested that treatment with metoclopramide reduces the risk of pneumonia in patients with acute stroke and a nasogastric tube. We assessed whether this finding could be replicated in a post hoc… read more here.
Keywords: nasogastric tube; pneumonia; trial; stroke nasogastric ... See more keywords
Effects of a Safety Letter on Metoclopramide Use in Korea: An Interrupted Time-Series Analysis
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DOI: 10.2147/rmhp.s263579
Abstract: Background The Korean Ministry of Food and Drug Safety (MFDS) issued a safety letter regarding metoclopramide use and its adverse drug event of extrapyramidal disorder in October 2013. However, this safety letter had controversial effects… read more here.
Keywords: prescription; metoclopramide; safety letter; use ... See more keywords
Ultrasonographic assessment of metoclopramide effect on gastric volume in parturients females undergoing Caesarean section: a randomized double blind study.
Sign Up to like & getrecommendations! Published in 2023 at "Minerva anestesiologica"
DOI: 10.23736/s0375-9393.22.16913-0
Abstract: BACKGROUND The prokinetic effect of metoclopramide promotes gastric emptying and decreases stomach capacity. The aim of the present study was to assess the efficacy of metoclopramide in reducing gastric contents and volume using gastric point-of-care… read more here.
Keywords: effect; gastric volume; metoclopramide; volume ... See more keywords
Evaluation of the effectiveness of preoperative administration of maropitant citrate and metoclopramide hydrochloride in preventing postoperative clinical gastroesophageal reflux in dogs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Veterinary Medical Association"
DOI: 10.2460/javma.255.4.437
Abstract: OBJECTIVE To investigate the prophylactic effectiveness of preoperative administration of maropitant citrate and metoclopramide hydrochloride in preventing postoperative clinical gastroesophageal reflux (GER) in dogs and to identify risk factors for clinical postoperative GER in dogs.… read more here.
Keywords: administration; maropitant; metoclopramide; postoperative clinical ... See more keywords
Comparison of enteral prucalopride versus intravenous metoclopramide for feeding intolerance in patients with critical illness: a randomized double-blinded study
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1413246
Abstract: Background Feeding intolerance is commonly experienced during enteral feeding, necessitating cessation. Metoclopramide may be given to assist gastric emptying, but patients experience adverse effects and gradual loss of efficacy. Prucalopride, a safer prokinetic, may play… read more here.
Keywords: group; prucalopride; feeding intolerance; study ... See more keywords
Comparison of the Blood–Brain Barrier Transport and Vulnerability to P-Glycoprotein-Mediated Drug–Drug Interaction of Domperidone versus Metoclopramide Assessed Using In Vitro Assay and PET Imaging
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14081658
Abstract: Domperidone and metoclopramide are widely prescribed antiemetic drugs with distinct neurological side effects. The impact of P-glycoprotein (P-gp)-mediated efflux at the blood–brain barrier (BBB) on brain exposure and BBB permeation was compared in vitro and… read more here.
Keywords: metoclopramide; brain; domperidone; drug ... See more keywords