Risk of clinically relevant hyperglycemia with metoprolol compared to carvedilol in older adults with heart failure and diabetes
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.5303
Abstract: Although prior literature suggests that metoprolol may worsen glucose control compared to carvedilol, whether this has clinical relevance among older adults with diabetes and heart failure (HF) remains an open question. read more here.
Keywords: metoprolol; older adults; heart failure; compared carvedilol ... See more keywords
Biodegradability of fluoxetine, mefenamic acid, and metoprolol using different microbial consortiums
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-8413-y
Abstract: The biodegradation of fluoxetine, mefenamic acid, and metoprolol using ammonium-nitrite-oxidizing consortium, nitrite-oxidizing consortium, and heterotrophic biomass was evaluated in batch tests applying different retention times. The ammonium-nitrite-oxidizing consortium presented the highest biodegradation percentages for mefenamic… read more here.
Keywords: acid metoprolol; consortium; biodegradation; mefenamic acid ... See more keywords
Pharmacometabolomics Detects Various Unreported Metoprolol Metabolites in Urine of (Potential) Living Kidney Donors and Kidney Transplant Recipients
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-025-01502-7
Abstract: Metoprolol is primarily metabolized via the polymorphic cytochrome P450-2D6 (CYP2D6) enzyme, which underlies interindividual variation in conversion rates and may benefit from pharmacogenetics-driven therapy personalization. However, the field relies heavily on knowledge of a drug’s… read more here.
Keywords: living kidney; metoprolol; kidney donors; potential living ... See more keywords
Pharmacokinetic analysis of modified‐release metoprolol formulations: An interspecies comparison
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2016.10.039
Abstract: &NA; In the current study, we investigated the metoprolol absorption kinetics of an in‐house produced oral sustained‐release formulation, matrices manufactured via prilling, and two commercially available formulations, ZOK‐ZID® (reservoir) and Slow‐Lopresor® (matrix) in both New… read more here.
Keywords: absorption; metoprolol; formulation; pharmacokinetic analysis ... See more keywords
Fungal treatment of metoprolol and its recalcitrant metabolite metoprolol acid in hospital wastewater: Biotransformation, sorption and ecotoxicological impact.
Sign Up to like & getrecommendations! Published in 2019 at "Water research"
DOI: 10.1016/j.watres.2018.12.054
Abstract: Hospital wastewater (HWW) effluents represent an important source of contaminants such as pharmaceutical compounds and their human metabolites. To better evaluate dedicated treatment of hospital effluents for pollutant mitigation, not only the parent compounds should… read more here.
Keywords: metoprolol acid; treatment; hospital; metoprolol ... See more keywords
Early Evaluation of the Interaction and Gender Differences in Combination of Apatinib and Metoprolol Using Humanized CYP2D6 Model.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.4c00433
Abstract: Apatinib, a commonly used tyrosine kinase inhibitor in cancer treatment, can cause adverse reactions such as hypertension. Hypertension, in turn, can increase the risk of certain cancers. The coexistence of these diseases makes the use… read more here.
Keywords: combination; metoprolol; apatinib metoprolol; using humanized ... See more keywords
Enantiospecific Uptake and Depuration Kinetics of Chiral Metoprolol and Venlafaxine in Marine Medaka (Oryzias melastigma): Tissue Distribution and Metabolite Formation.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c08379
Abstract: The increasing use of chiral pharmaceuticals has led to their widespread presence in the environment. However, their toxicokinetics have rarely been reported. Therefore, the tissue-specific uptake and depuration kinetics of two pairs of pharmaceutical enantiomers,… read more here.
Keywords: depuration; venlafaxine; uptake depuration; depuration kinetics ... See more keywords
Association of histamine with hypertension-induced cardiac remodeling and reduction of hypertrophy with the histamine-2-receptor antagonist famotidine compared with the beta-blocker metoprolol
Sign Up to like & getrecommendations! Published in 2018 at "Hypertension Research"
DOI: 10.1038/s41440-018-0109-2
Abstract: The association of histamine with adverse cardiac remodeling in chronic pressure overload has not received much attention. A pilot study in spontaneously hypertensive rats (SHRs) indicated a reduction of left ventricular hypertrophy (LVH) with a… read more here.
Keywords: reduction; famotidine; metoprolol; histamine ... See more keywords
Metoprolol therapy in patients with Eisenmenger syndrome (MINES) study. A single-centre, double-blinded, randomised, placebo-controlled trial
Sign Up to like & getrecommendations! Published in 2024 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehae666.2181
Abstract: Prevalence of Eisenmenger syndrome is still common in developing countries where early neonatal screening and referral for surgery is seldom possible. Limited number of drugs are available for treatment of this condition. Beta-blockers may improve… read more here.
Keywords: patients eisenmenger; therapy; metoprolol; group ... See more keywords
Pulmonary Delivery of Metoprolol Reduces Ventricular Rate during Atrial Fibrillation and Accelerates Conversion to Sinus Rhythm.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000780
Abstract: BACKGROUND Safe, effective pulmonary delivery of cardioactive agents in humans is under development. OBJECTIVES We examined whether intratracheal delivery of metoprolol can reduce ventricular rate during atrial fibrillation (AF) and accelerate conversion to sinus rhythm.… read more here.
Keywords: ventricular rate; sinus rhythm; rate; delivery ... See more keywords
The impact of CYP2D6 mediated drug–drug interaction: a systematic review on a combination of metoprolol and paroxetine/fluoxetine
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13741
Abstract: Aim Metoprolol (a CYP2D6 substrate) is often co‐prescribed with paroxetine/fluoxetine (a CYP2D6 inhibitor) because the clinical relevance of this drug–drug interaction (DDI) is still unclear. This review aimed to systematically evaluate the available evidence and… read more here.
Keywords: drug interaction; metoprolol; drug; paroxetine fluoxetine ... See more keywords