Risk of clinically relevant hyperglycemia with metoprolol compared to carvedilol in older adults with heart failure and diabetes
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.5303
Abstract: Although prior literature suggests that metoprolol may worsen glucose control compared to carvedilol, whether this has clinical relevance among older adults with diabetes and heart failure (HF) remains an open question. read more here.
Keywords: metoprolol; older adults; heart failure; compared carvedilol ... See more keywords
Biodegradability of fluoxetine, mefenamic acid, and metoprolol using different microbial consortiums
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-8413-y
Abstract: The biodegradation of fluoxetine, mefenamic acid, and metoprolol using ammonium-nitrite-oxidizing consortium, nitrite-oxidizing consortium, and heterotrophic biomass was evaluated in batch tests applying different retention times. The ammonium-nitrite-oxidizing consortium presented the highest biodegradation percentages for mefenamic… read more here.
Keywords: acid metoprolol; consortium; biodegradation; mefenamic acid ... See more keywords
Pharmacokinetic analysis of modified‐release metoprolol formulations: An interspecies comparison
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2016.10.039
Abstract: &NA; In the current study, we investigated the metoprolol absorption kinetics of an in‐house produced oral sustained‐release formulation, matrices manufactured via prilling, and two commercially available formulations, ZOK‐ZID® (reservoir) and Slow‐Lopresor® (matrix) in both New… read more here.
Keywords: absorption; metoprolol; formulation; pharmacokinetic analysis ... See more keywords
Fungal treatment of metoprolol and its recalcitrant metabolite metoprolol acid in hospital wastewater: Biotransformation, sorption and ecotoxicological impact.
Sign Up to like & getrecommendations! Published in 2019 at "Water research"
DOI: 10.1016/j.watres.2018.12.054
Abstract: Hospital wastewater (HWW) effluents represent an important source of contaminants such as pharmaceutical compounds and their human metabolites. To better evaluate dedicated treatment of hospital effluents for pollutant mitigation, not only the parent compounds should… read more here.
Keywords: metoprolol acid; treatment; hospital; metoprolol ... See more keywords
Enantiospecific Uptake and Depuration Kinetics of Chiral Metoprolol and Venlafaxine in Marine Medaka (Oryzias melastigma): Tissue Distribution and Metabolite Formation.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c08379
Abstract: The increasing use of chiral pharmaceuticals has led to their widespread presence in the environment. However, their toxicokinetics have rarely been reported. Therefore, the tissue-specific uptake and depuration kinetics of two pairs of pharmaceutical enantiomers,… read more here.
Keywords: depuration; venlafaxine; uptake depuration; depuration kinetics ... See more keywords
Association of histamine with hypertension-induced cardiac remodeling and reduction of hypertrophy with the histamine-2-receptor antagonist famotidine compared with the beta-blocker metoprolol
Sign Up to like & getrecommendations! Published in 2018 at "Hypertension Research"
DOI: 10.1038/s41440-018-0109-2
Abstract: The association of histamine with adverse cardiac remodeling in chronic pressure overload has not received much attention. A pilot study in spontaneously hypertensive rats (SHRs) indicated a reduction of left ventricular hypertrophy (LVH) with a… read more here.
Keywords: reduction; famotidine; metoprolol; histamine ... See more keywords
Pulmonary Delivery of Metoprolol Reduces Ventricular Rate during Atrial Fibrillation and Accelerates Conversion to Sinus Rhythm.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000780
Abstract: BACKGROUND Safe, effective pulmonary delivery of cardioactive agents in humans is under development. OBJECTIVES We examined whether intratracheal delivery of metoprolol can reduce ventricular rate during atrial fibrillation (AF) and accelerate conversion to sinus rhythm.… read more here.
Keywords: ventricular rate; sinus rhythm; rate; delivery ... See more keywords
The impact of CYP2D6 mediated drug–drug interaction: a systematic review on a combination of metoprolol and paroxetine/fluoxetine
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DOI: 10.1111/bcp.13741
Abstract: Aim Metoprolol (a CYP2D6 substrate) is often co‐prescribed with paroxetine/fluoxetine (a CYP2D6 inhibitor) because the clinical relevance of this drug–drug interaction (DDI) is still unclear. This review aimed to systematically evaluate the available evidence and… read more here.
Keywords: drug interaction; metoprolol; drug; paroxetine fluoxetine ... See more keywords
Metoprolol Mitigates Ischemic Heart Remodeling and Fibrosis by Increasing the Expression of AKAP5 in Ischemic Heart
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DOI: 10.1155/2022/5993459
Abstract: The harm of heart failure mainly causes patients to develop dyspnea, fatigue, fluid retention, and other symptoms, which impair patients' activity tolerance and lead to a dramatic decrease in patients' quality of life. The purpose… read more here.
Keywords: ischemic heart; remodeling fibrosis; expression; metoprolol ... See more keywords
Analytical Method Development and Validation for Simultaneous Estimation of Trimetazidine Hydrochloride and Metoprolol Succinate Using HPTLC
Sign Up to like & getrecommendations! Published in 2019 at "Current Pharmaceutical Analysis"
DOI: 10.2174/1573412913666171201160329
Abstract: Trimetazidine and Metoprolol combination is more effective in the treatment of cardiac disorders as compared to single drug therapy.Background: A rapid, simple, and sensitive HPTLC method was developed for the simultaneous determination of Trimetazidine and… read more here.
Keywords: hydrochloride metoprolol; method; metoprolol; metoprolol succinate ... See more keywords
Baseline Corrected QT Interval Dispersion Is Useful to Predict Effectiveness of Metoprolol on Pediatric Postural Tachycardia Syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.808512
Abstract: Objectives The study was designed to explore the role of baseline-corrected QT interval dispersion (QTcd) in predicting the effectiveness of metoprolol on pediatric postural tachycardia syndrome (POTS). Methods There were two groups in the study,… read more here.
Keywords: effectiveness metoprolol; metoprolol; baseline; metoprolol pediatric ... See more keywords