A smart gelatin nanoparticle for delivery of metoprolol succinate: A strategy for enhancing the therapeutic efficacy by improving bioavailability
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.101214
Abstract: Abstract The purpose of this study was to develop and evaluate of gelatin nanoparticles (GNPs) by nanoprecipitation method to increase metoprolol succinate (MES) peroral bioavailability. Prepared GNPs were evaluated in terms of its properties such… read more here.
Keywords: bioavailability; therapeutic efficacy; drug; release ... See more keywords
Analytical Method Development and Validation for Simultaneous Estimation of Trimetazidine Hydrochloride and Metoprolol Succinate Using HPTLC
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DOI: 10.2174/1573412913666171201160329
Abstract: Trimetazidine and Metoprolol combination is more effective in the treatment of cardiac disorders as compared to single drug therapy.Background: A rapid, simple, and sensitive HPTLC method was developed for the simultaneous determination of Trimetazidine and… read more here.
Keywords: hydrochloride metoprolol; method; metoprolol; metoprolol succinate ... See more keywords
Development of a Scalable Process of Film-Coated bi-Layer Tablet Containing Sustained-Release Metoprolol Succinate and Immediate-Release Amlodipine Besylate
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DOI: 10.3390/pharmaceutics13111797
Abstract: The development of new drugs that combine active ingredients for the treatment hypertension is critically essential owing to its offering advantages for both patients and manufacturers. In this study, for the first time, detailed development… read more here.
Keywords: scalable process; process; film coated; metoprolol succinate ... See more keywords
To Enhance the Physicochemical Properties of Metoprolol Succinate By Co-Crystal Technique
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DOI: 10.5958/0974-360x.2017.00683.7
Abstract: Metoprolol succinate is a selective beta receptor blocker having poor physico-chemical and micromeritic properties. Therefore the co-crystals of metoprolol have been attempted to improve its physic-chemical and micromeritic characteristics. The effect of different co-formers such… read more here.
Keywords: metoprolol succinate; crystal technique; physicochemical properties; enhance physicochemical ... See more keywords