Activated Hepatic Nuclear Factor-κB in Experimental Colitis Regulates CYP2A5 and Metronidazole Disposition.
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DOI: 10.1021/acs.molpharmaceut.2c00890
Abstract: Systemic exposure of metronidazole is increased in patients with inflammatory bowel diseases (IBDs), while the underlying mechanism remains unknown. Here, we aim to decipher the mechanisms by which experimental colitis regulates metronidazole disposition in mice.… read more here.
Keywords: metronidazole disposition; colitis regulates; colitis; experimental colitis ... See more keywords