Pharmacokinetic and Pharmacodynamic Properties of Metronidazole in Pediatric Patients With Acute Appendicitis: A Prospective Study.
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DOI: 10.1093/jpids/piy040
Abstract: Background Metronidazole is traditionally dosed every 6-8 hours even though in adults it has a long half-life, concentration-dependent killing, and 3-hour postantibiotic effect. Based on this logic, some pediatric hospitals adopted once-daily dosing for appendicitis,… read more here.
Keywords: pharmacodynamic properties; properties metronidazole; target attainment; metronidazole pediatric ... See more keywords