Roles of efflux pumps and nitroreductases in metronidazole-resistant Trichomonas vaginalis
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DOI: 10.1007/s00436-025-08463-7
Abstract: Trichomonas vaginalis infections significantly impact public health and are associated with increased likelihood of HIV infection, prostate cancer, and pregnancy complications. Current treatment relies almost exclusively on 5-nitroimidazoles, particularly metronidazole, raising concerns about drug resistance… read more here.
Keywords: resistance; efflux pump; trichomonas vaginalis; metronidazole resistant ... See more keywords
Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates
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DOI: 10.3201/eid2811.220615
Abstract: The plasmid pCD-METRO confers metronidazole resistance in Clostridioides difficile. We showed high sequence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and associated metronidazole-resistant isolates in clinical and veterinary reservoirs in the Americas.… read more here.
Keywords: clostridioides difficile; metronidazole resistant; pcd metro; sequence based ... See more keywords
Characterization of Metronidazole-Resistant Giardia intestinalis Lines by Comparative Transcriptomics and Proteomics
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DOI: 10.3389/fmicb.2022.834008
Abstract: Metronidazole (MTZ) is a clinically important antimicrobial agent that is active against both bacterial and protozoan organisms. MTZ has been used extensively for more than 60 years and until now resistance has been rare. However,… read more here.
Keywords: giardia; mtz resistance; metronidazole resistant; resistance ... See more keywords