Metronomic Chemotherapy vs Best Supportive Care in Progressive Pediatric Solid Malignant Tumors: A Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.0324
Abstract: Importance Although oral metronomic chemotherapy is often used in progressive pediatric solid malignant tumors, a literature review reveals that only small single-arm retrospective or phase 1 and 2 studies have been performed. Skepticism abounds because… read more here.
Keywords: chemotherapy; pfs; trial; metronomic chemotherapy ... See more keywords
Assessing Metronomic Chemotherapy for Progressive Pediatric Solid Malignant Tumors.
Sign Up to like & getrecommendations! Published in 2018 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2017.3983
Abstract: Assessing Metronomic Chemotherapy for Progressive Pediatric Solid Malignant Tumors To the Editor In the trial conducted by Pramanik and colleagues1 for treating progressive pediatric solid malignant tumors, the primary end point was progression-free survival (PFS).… read more here.
Keywords: chemotherapy; pfs; metronomic chemotherapy; solid malignant ... See more keywords
Metronomic chemotherapy for advanced breast cancer patients in the real world practice: Final results of the VICTOR-6 study.
Sign Up to like & getrecommendations! Published in 2019 at "Breast"
DOI: 10.1016/j.breast.2019.07.006
Abstract: Metronomic chemotherapy (mCHT) refers to the minimum biologically effective dose of a chemotherapy agent given as a continuous dosing regimen, with no prolonged drug-free breaks, that leads to antitumor activity. Aim of the present study… read more here.
Keywords: chemotherapy; victor study; metronomic chemotherapy; breast cancer ... See more keywords
Metronomic chemotherapy in head and neck cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2016.10.047
Abstract: Head neck cancer (HNC) is generally treated with a multimodality approach. Loco-regional-distant control is often worst, due to the advantage stage disease at diagnosis and the optimal treatment option remains an unresolved issue. Metronomic chemotherapy… read more here.
Keywords: cancer; neck cancer; metronomic chemotherapy; head neck ... See more keywords
Metronomic chemotherapy and immunotherapy in cancer treatment.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.01.040
Abstract: Systemic chemotherapy given at maximum tolerated doses (MTD) has been the mainstay of cancer treatment for more than half a century. In some chemosensitive diseases such as hematologic malignancies and solid tumors, MTD has led… read more here.
Keywords: chemotherapy; immunotherapy; metronomic chemotherapy; cancer treatment ... See more keywords
Does metronomic chemotherapy induce tumor angiogenic dormancy? A review of available preclinical and clinical data.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.06.002
Abstract: Tumor dormancy is the ability of cancer cells to survive in a non-proliferating state. This condition can depend on three main mechanisms: cell cycle arrest (quiescence or cell dormancy), immunosurveillance (immunologic dormancy), or lack of… read more here.
Keywords: dormancy; metronomic chemotherapy; angiogenic dormancy; angiogenic factors ... See more keywords
A Mechanistic Review of Methotrexate and Celecoxib as a Potential Metronomic Chemotherapy for Oral Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Investigation"
DOI: 10.1080/07357907.2022.2139840
Abstract: Abstract The combination of low-dose methotrexate and celecoxib as metronomic chemotherapy (MCT) is a novel therapy, believed to act by modulating the immune response, inhibiting angiogenesis and its cytotoxic action, though the exact mechanism of… read more here.
Keywords: cell carcinoma; squamous cell; methotrexate celecoxib; metronomic chemotherapy ... See more keywords
Metronomic chemotherapy combined with endocrine therapy: are we challenging some dogmas?
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2020.1782200
Abstract: ABSTRACT Introduction Metronomic chemotherapy exerts its effects via inhibition of angiogenesis, immune modulation of the tumoral stroma, induction of senescence and apoptosis of tumor cells. Due to its favorable toxicity profile and its oral administration,… read more here.
Keywords: chemotherapy; endocrine therapy; metronomic chemotherapy; breast cancer ... See more keywords
Efficacy and safety of metronomic chemotherapy in maintenance therapy for metastatic colorectal cancer: A systematic review of randomized controlled trials
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DOI: 10.1097/md.0000000000031659
Abstract: Background: The current studies on metronomic chemotherapy in mCRC are all aimed at patients after multi-line therapy failure, and only a few studies have focused on maintenance treatment after successful first-line therapy. Methods: The PubMed,… read more here.
Keywords: maintenance; mpfs; randomized controlled; therapy ... See more keywords
Metronomic chemotherapy in patients with advanced neuroendocrine tumors: A single‐center retrospective analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.13189
Abstract: Neuroendocrine tumors (NETs) are more commonly slow‐growing, therefore patients often receive chronic systemic therapies for tumor growth control and preservation of quality of life. Metronomic chemotherapy (mCT) is in line with this goal as it… read more here.
Keywords: mct; metronomic chemotherapy; neuroendocrine tumors; analysis ... See more keywords
Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Oncology"
DOI: 10.1155/2019/5483791
Abstract: Metronomic chemotherapy, continuous and dose-dense administration of chemotherapeutic drugs with lowered doses, is being evaluated for substituting, augmenting, or appending conventional maximum tolerated dose regimens, with preclinical and clinical studies for the past few decades.… read more here.
Keywords: chemotherapy; systematic review; metronomic chemotherapy; review literature ... See more keywords