LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "mettl14" as a keyword



Downregulation of m6A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness

Sign Up to like & get
recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13181

Abstract: N6‐methyladenosine (m6A) and its regulatory proteins have been associated with tumorigenesis in several cancer types. However, knowledge on the mechanistic network related to m6A in bladder cancer (BlCa) is rather limited, requiring further investigation of… read more here.

Keywords: writer complex; m6a; tumor aggressiveness; m6a writer ... See more keywords

METTL14‐Induced M6A Methylation Increases G6pc Biosynthesis, Hepatic Glucose Production and Metabolic Disorders in Obesity

Sign Up to like & get
recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202417355

Abstract: METTL14 dimerizes with METTL3 to install N6‐methyladenosine (m6A) on mRNA (m6A writers). Subsequently, m6A readers bind to m6A‐marked RNA to influence its metabolism. RNA m6A emerges to critically regulate multiple intracellular processes; however, there is… read more here.

Keywords: hepatic glucose; m6a; g6pc; mettl14 ... See more keywords

Mettl14 Deficiency Promotes Fam32a Expression via m6A Modifications to Facilitate the Hepatocyte G1/S Transition

Sign Up to like & get
recommendations! Published in 2025 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.70102

Abstract: Mettl14, a key component of the m6A methyltransferase complex, plays a crucial role in regulating mRNA stability and splicing. Reduced expression of Mettl14 is associated with hepatocellular carcinoma and liver regeneration, yet the molecular mechanisms… read more here.

Keywords: mettl14 deficiency; mettl14; fam32a expression; transition ... See more keywords

METTL14 represses osteoclast formation to ameliorate osteoporosis via enhancing GPX4 mRNA stability.

Sign Up to like & get
recommendations! Published in 2023 at "Environmental toxicology"

DOI: 10.1002/tox.23829

Abstract: Excessive bone resorption by osteoclasts results in the development of multiple bone disorders including osteoporosis. This study aimed to explore the biological function of methyltransferase-like14 (METTL14) in osteoclast formation, as well as its related mechanisms.… read more here.

Keywords: via enhancing; bone; osteoporosis; formation ... See more keywords

METTL14 regulates inflammation in ulcerative colitis via the lncRNA DHRS4-AS1/miR-206/A3AR axis

Sign Up to like & get
recommendations! Published in 2024 at "Cell Biology and Toxicology"

DOI: 10.1007/s10565-024-09944-8

Abstract: As a chronic inflammatory bowel disease, the pathogenesis of ulcerative colitis (UC) has not been fully elucidated. N6-methyladenosine (m6A) modification, observed in various RNAs, is implicated in inflammatory bowel diseases. Methyltransferase-like 14 (METTL14) is the… read more here.

Keywords: dhrs4 as1; a3ar axis; mir 206; mettl14 ... See more keywords

Enzymatically Mediated In Situ Generation of Z-Scheme Bi2S3/Bi2MoO6 Heterojunction-Based Organic Photoelectrochemical Transistor for METTL3/METTL14 Detection.

Sign Up to like & get
recommendations! Published in 2024 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.4c01610

Abstract: The OPECT biosensing platform, which connects optoelectronics and biological systems, offers significant amplification and more possibilities for research in biological applications. In this work, a homogeneous organic photoelectrochemical transistor (OPECT) biosensor based on a Bi2S3/Bi2MoO6… read more here.

Keywords: mettl14; bi2moo6 heterojunction; mettl3 mettl14; bi2s3 bi2moo6 ... See more keywords

METTL14-mediated m6A mRNA modification of G6PD promotes lung adenocarcinoma

Sign Up to like & get
recommendations! Published in 2024 at "Cell Death Discovery"

DOI: 10.1038/s41420-024-02133-w

Abstract: METTL14 functions as an RNA methyltransferase involved in m6A modification, influencing mRNA biogenesis, decay, and translation processes. However, the specific mechanism by which METTL14 regulates glucose-6-phosphate dehydrogenase (G6PD) to promote the progression of lung adenocarcinoma… read more here.

Keywords: g6pd; mettl14; lung adenocarcinoma; mettl14 mediated ... See more keywords

METTL14 suppresses the migration and invasion of hepatocellular carcinoma cells by m6A methylation of RPLP2

Sign Up to like & get
recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-87701-5

Abstract: Fluctuating N(6)-methyladenosine (m6A) levels affect the progression of hepatocellular carcinoma (HCC). METTL14, a m6A methyltransferase, acts as a tumor suppressor in HCC; however, its underlying mechanisms need further clarification. This study aimed to clarify the… read more here.

Keywords: mettl14; hcc; hepatocellular carcinoma; migration invasion ... See more keywords

Deletion of METTL14, a key methylation regulator, attenuates vascular ageing

Sign Up to like & get
recommendations! Published in 2025 at "European Heart Journal"

DOI: 10.1093/eurheartj/ehaf476

Abstract: Abstract Background and Aims Vascular ageing often accompanies inflammation, contributing to the onset of local or systemic vascular diseases. Nevertheless, limited research focuses on pivotal factors triggering chronic vascular inflammation and associated pathological changes. This… read more here.

Keywords: mettl14 key; mettl14; aortic endothelial; deletion mettl14 ... See more keywords

Recognition of G-quadruplex RNA by a crucial RNA methyltransferase component, METTL14

Sign Up to like & get
recommendations! Published in 2021 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkab1211

Abstract: Abstract N6-methyladenosine (m6A) is an important epitranscriptomic chemical modification that is mainly catalyzed by the METTL3/METTL14 RNA methyltransferase heterodimer. Although m6A is found at the consensus sequence of 5′-DRACH-3′ in various transcripts, the mechanism by… read more here.

Keywords: rna methyltransferase; mettl14; mettl3 mettl14; rna ... See more keywords

METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity.

Sign Up to like & get
recommendations! Published in 2023 at "Protein & cell"

DOI: 10.1093/procel/pwad009

Abstract: METTL3 and METTL14 are two components that form the core heterodimer of the main RNA m6A methyltransferase complex (MTC) that installs m6A. Surprisingly, depletion of METTL3 or METTL14 displayed distinct effects on stemness maintenance of… read more here.

Keywords: rna; mettl14 chromatin; methyltransferase; mettl3 mettl14 ... See more keywords