Methyl-Transferase-Like Protein 16 (METTL16): The Intriguing Journey of a Key Epitranscriptomic Player Becoming an Emerging Biological Target.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c01247
Abstract: Key epitranscriptomic players have been increasingly characterized for their structural features and their involvement in several diseases. Accordingly, the design and synthesis of novel epitranscriptomic modulators have started opening a glimmer for drug discovery. m6A… read more here.
Keywords: mettl16; like protein; methyl transferase; transferase like ... See more keywords
The m6A methyltransferase METTL16 negatively regulates MCP1 expression in mesenchymal stem cells during monocyte recruitment
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.162436
Abstract: Mesenchymal stem cells (MSCs) possess strong immunoregulatory functions, one aspect of which is recruiting monocytes from peripheral vessels to local tissue by secreting monocyte chemoattractant protein 1 (MCP1). However, the regulatory mechanisms of MCP1 secretion… read more here.
Keywords: mettl16; expression; mesenchymal stem; mscs ... See more keywords
RNA Methyltransferase Mettl16 Is Indispensable for the Survival of Naïve CD4+ T Cells In Vivo
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DOI: 10.1182/blood-2024-198338
Abstract: Revealing T cell hematopoiesis is essential for understanding the mechanisms of acquired immunity and the various diseases associated with its disruption. N6-methyladenosine (m6A) modification is one of the most abundant modifications in eukaryotic mRNAs and… read more here.
Keywords: mice; control; mettl16; compared control ... See more keywords
Characterization of METTL16 as a cytoplasmic RNA binding protein
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DOI: 10.1371/journal.pone.0227647
Abstract: mRNA modification by N6-methyladenosine (m6A) is involved in many post-transcriptional regulation processes including mRNA stability, splicing and promotion of translation. Accordingly, the recently identified mRNA methylation complex containing METTL3, METTL14, and WTAP has been the… read more here.
Keywords: rna; rna binding; mettl16 cytoplasmic; mettl16 ... See more keywords
METTL16 Contributes to Coronary Heart Disease by Inducing TET2 m6A Modification
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s487828
Abstract: Background Coronary heart disease (CHD) ranks as the primary cause of global morbidity and mortality. Despite of the progress in exploring risk factors and developing medications, considerable residual risk persists. In recent years, epigenetic regulation… read more here.
Keywords: coronary heart; mettl16; m6a modification; heart disease ... See more keywords
The Role of the m6A RNA Methyltransferase METTL16 in Gene Expression and SAM Homeostasis
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DOI: 10.3390/genes13122312
Abstract: The RNA methylation of adenosine at the N6-position (m6A) has attracted significant attention because of its abundance and dynamic nature. It accounts for more than 80% of all RNA modifications present in bacteria and eukaryotes… read more here.
Keywords: m6a; methyltransferase; gene expression; mettl16 ... See more keywords
METTL16, Methyltransferase-Like Protein 16: Current Insights into Structure and Function
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22042176
Abstract: Methyltransferase-like protein 16 (METTL16) is a human RNA methyltransferase that installs m6A marks on U6 small nuclear RNA (U6 snRNA) and S-adenosylmethionine (SAM) synthetase pre-mRNA. METTL16 also controls a significant portion of m6A epitranscriptome by… read more here.
Keywords: methyltransferase like; rna; methyltransferase; like protein ... See more keywords