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   Articles with "mettl16" as a keyword



The m6A methyltransferase METTL16 negatively regulates MCP1 expression in mesenchymal stem cells during monocyte recruitment

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recommendations! Published in 2023 at "JCI Insight"

DOI: 10.1172/jci.insight.162436

Abstract: Mesenchymal stem cells (MSCs) possess strong immunoregulatory functions, one aspect of which is recruiting monocytes from peripheral vessels to local tissue by secreting monocyte chemoattractant protein 1 (MCP1). However, the regulatory mechanisms of MCP1 secretion… read more here.

Keywords: mettl16; expression; mesenchymal stem; mscs ... See more keywords

Characterization of METTL16 as a cytoplasmic RNA binding protein

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recommendations! Published in 2020 at "PLoS ONE"

DOI: 10.1371/journal.pone.0227647

Abstract: mRNA modification by N6-methyladenosine (m6A) is involved in many post-transcriptional regulation processes including mRNA stability, splicing and promotion of translation. Accordingly, the recently identified mRNA methylation complex containing METTL3, METTL14, and WTAP has been the… read more here.

Keywords: rna; rna binding; mettl16 cytoplasmic; mettl16 ... See more keywords
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The Role of the m6A RNA Methyltransferase METTL16 in Gene Expression and SAM Homeostasis

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recommendations! Published in 2022 at "Genes"

DOI: 10.3390/genes13122312

Abstract: The RNA methylation of adenosine at the N6-position (m6A) has attracted significant attention because of its abundance and dynamic nature. It accounts for more than 80% of all RNA modifications present in bacteria and eukaryotes… read more here.

Keywords: m6a; methyltransferase; gene expression; mettl16 ... See more keywords
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METTL16, Methyltransferase-Like Protein 16: Current Insights into Structure and Function

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22042176

Abstract: Methyltransferase-like protein 16 (METTL16) is a human RNA methyltransferase that installs m6A marks on U6 small nuclear RNA (U6 snRNA) and S-adenosylmethionine (SAM) synthetase pre-mRNA. METTL16 also controls a significant portion of m6A epitranscriptome by… read more here.

Keywords: methyltransferase like; rna; methyltransferase; like protein ... See more keywords