METTL3 Mediates Epithelial-Mesenchymal Transition by Modulating FOXO1 mRNA N6 -Methyladenosine-Dependent YTHDF2 Binding: A Novel Mechanism of Radiation-Induced Lung Injury.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202204784
Abstract: The biological roles of epithelial-mesenchymal transition (EMT) in the pathogenesis of radiation-induced lung injury (RILI) have been widely demonstrated, but the mechanisms involved have been incompletely elucidated. N6 -methyladenosine (m6 A) modification, the most abundant… read more here.
Keywords: ythdf2; modification; epithelial mesenchymal; radiation induced ... See more keywords
METTL3 expression is associated with glycolysis metabolism and sensitivity to glycolytic stress in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.2918
Abstract: METTL3 is an RNA methyltransferase implicated in the control of cell differentiation and proliferation in embryonic development and cancer. The current study was aimed to explore the function and underlying mechanism of METTL3 in hepatocellular… read more here.
Keywords: hepatocellular carcinoma; hcc; glycolysis; mettl3 ... See more keywords
Discovery of substituted indole derivatives as allosteric inhibitors of m6A‐RNA methyltransferase, METTL3‐14 complex
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DOI: 10.1002/ddr.21910
Abstract: m6A RNA methyltransferase (METTL3‐14) catalyzes the methylation of adenosine in mRNA and plays important roles in mRNA functions, and it has been implicated in the progression of multiple cancers, including acute myeloid leukemia (AML). In… read more here.
Keywords: m6a rna; mettl3 complex; rna methyltransferase; methyltransferase mettl3 ... See more keywords
METTL3‐Mediated m6A mRNA Methylation Modulates Tooth Root Formation by Affecting NFIC Translation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4180
Abstract: N6‐methyladenosine (m6A), as a eukaryotic mRNA modification catalyzed by methyltransferase METTL3, is involved in various processes of development or diseases via regulating RNA metabolism. However, the effect of METTL3‐mediated m6A modification in tooth development has… read more here.
Keywords: mettl3 mediated; mediated m6a; mettl3; root formation ... See more keywords
METTL3 mediated m6A modification plays an oncogenic role in cutaneous squamous cell carcinoma by regulating ΔNp63.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.155
Abstract: The cutaneous squamous cell carcinoma (cSCC) originates from epithelial stem cells through the dysregulation of self-renewal and differentiation. Recent studies have identified methyltransferase-like 3 (METTL3)-mediated N6-methyladenosine (m6A) modification as key regulator of fate of stem… read more here.
Keywords: cell carcinoma; squamous cell; mettl3; cutaneous squamous ... See more keywords
Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m6A modification.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116182
Abstract: N6-methyladenosine (m6A) methylation is one of the most common internal modifications in eukaryotic messenger RNA occurring on N6 nitrogen of adenosine. However, the roles of m6A in temporomandibular joint osteoarthritis (TMJ OA) are still elusive.… read more here.
Keywords: m6a modification; mettl3; apoptosis autophagy; autophagy chondrocytes ... See more keywords
LXA4 enhances prostate cancer progression by facilitating M2 macrophage polarization via inhibition of METTL3.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108586
Abstract: Tumor-associated macrophages (TAMs) are major innate immune cells that play crucial roles in prostate cancer onset and progression. Recently, increasing evidence has suggested that elevated N6-adenine methylation of mRNA is observed in prostate cancer tissues… read more here.
Keywords: cancer; mettl3; progression; prostate cancer ... See more keywords
m6A-dependent upregulation of TRAF6 by METTL3 is associated with metastatic osteosarcoma
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DOI: 10.1016/j.jbo.2022.100411
Abstract: Highlights • METTL3 is highly expressed in osteosarcoma.• METTL3 downregulation inhibits metastases of osteosarcoma cells.• m6A regulates osteosarcoma cell activity.• METTL3 modifies TRAF6 activity via m6A.• TRAF6 inhibits the repressive effects of sh-METTL3 on osteosarcoma… read more here.
Keywords: upregulation traf6; mettl3; m6a dependent; osteosarcoma ... See more keywords
The function of the m6A methyltransferase METTL3 in goat early embryo development under hypoxic and normoxic conditions.
Sign Up to like & getrecommendations! Published in 2021 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2021.10.017
Abstract: It has been reported that N6-methyladenosine (m6A) methyltransferase-like 3 (METTL3) plays an important role in zygote genome activation during embryonic development, but the effects of METTL3 under oxidative stress in the early development of goat… read more here.
Keywords: mettl3; normoxic conditions; m6a methyltransferase; cell ... See more keywords
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01601
Abstract: RNA methylation is a critical mechanism for regulating the transcription and translation of specific sequences or for eliminating unnecessary sequences during RNA maturation. METTL3, an RNA methyltransferase that catalyzes the transfer of a methyl group… read more here.
Keywords: medicinal chemistry; mettl3 target; chemistry; validation first ... See more keywords
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0683-z
Abstract: N6-methyladenosine (m6A) is the most abundant modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in many bioprocesses. However, its functions in bladder cancer (BCa) remain elusive. Here, we discovered that methyltransferase-like 3 (METTL3),… read more here.
Keywords: bladder cancer; network; bca; methyltransferase ... See more keywords