METTL3/METTL14 Transactivation and m6A-Dependent TGF-β1 Translation in Activated Kupffer Cells
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2021.05.007
Abstract: Background and Aims Transforming growth factor β1 (TGF-β1) secreted from activated Kupffer cells (KC) promotes the progression of nonalcoholic steatohepatitis (NASH) to liver fibrosis. N6-methyladenosine (m6A) RNA modification participates in various cell stress responses, yet… read more here.
Keywords: tgf; mettl3 mettl14; m6a; activated kupffer ... See more keywords
m6A RNA methylation regulates the fate of endogenous retroviruses.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-020-03135-1
Abstract: Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and… read more here.
Keywords: rna methylation; methylation; endogenous retroviruses; mettl3 mettl14 ... See more keywords
Recognition of G-quadruplex RNA by a crucial RNA methyltransferase component, METTL14
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1211
Abstract: Abstract N6-methyladenosine (m6A) is an important epitranscriptomic chemical modification that is mainly catalyzed by the METTL3/METTL14 RNA methyltransferase heterodimer. Although m6A is found at the consensus sequence of 5′-DRACH-3′ in various transcripts, the mechanism by… read more here.
Keywords: rna methyltransferase; mettl14; mettl3 mettl14; rna ... See more keywords
METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity.
Sign Up to like & getrecommendations! Published in 2023 at "Protein & cell"
DOI: 10.1093/procel/pwad009
Abstract: METTL3 and METTL14 are two components that form the core heterodimer of the main RNA m6A methyltransferase complex (MTC) that installs m6A. Surprisingly, depletion of METTL3 or METTL14 displayed distinct effects on stemness maintenance of… read more here.
Keywords: rna; mettl14 chromatin; methyltransferase; mettl3 mettl14 ... See more keywords
METTL3/14 and IL-17 signaling contribute to CEBPA-DT enhanced oral cancer cisplatin resistance.
Sign Up to like & getrecommendations! Published in 2021 at "Oral diseases"
DOI: 10.1111/odi.14083
Abstract: OBJECTIVES Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Chemotherapy has been recognized as an optional combination treatment, which enhance the overall survival of OSCC patients. However, the majority of… read more here.
Keywords: chemoresistance; oscc chemoresistance; cebpa; resistance ... See more keywords
RNA secondary structure dependence in METTL3–METTL14 mRNA methylation is modulated by the N-terminal domain of METTL3
Sign Up to like & getrecommendations! Published in 2020 at "Biological Chemistry"
DOI: 10.1515/hsz-2020-0265
Abstract: Abstract N6-methyladenosine (m6A) is the most abundant modification in mRNA. The core of the human N6-methyltransferase complex (MTC) is formed by a heterodimer consisting of METTL3 and METTL14, which specifically catalyzes m6A formation within an… read more here.
Keywords: mettl3; methylation; secondary structure; mettl3 mettl14 ... See more keywords
The m6A RNA methyltransferase METTL3/METTL14 promotes leukemogenesis through the mdm2/p53 pathway in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.60381
Abstract: N6-methyladenosine (m6A) is the most abundant internal modification in mammalian mRNA and recent studies have highlighted the importance of m6A levels in tumor development. In this study, we investigated the expression of methyltransferase-like 3 (METTL3)… read more here.
Keywords: methyltransferase; mettl14; mettl3 mettl14; m6a ... See more keywords