METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey
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DOI: 10.1021/acs.jmedchem.2c01601
Abstract: RNA methylation is a critical mechanism for regulating the transcription and translation of specific sequences or for eliminating unnecessary sequences during RNA maturation. METTL3, an RNA methyltransferase that catalyzes the transfer of a methyl group… read more here.
Keywords: medicinal chemistry; mettl3 target; chemistry; validation first ... See more keywords