Metyrapone abolishes Spike-Wave Discharge seizures in GAERS by reducing stress hormones.
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DOI: 10.1111/epi.17584
Abstract: OBJECTIVE Stress is one of the most commonly reported triggers for seizures in patients with epilepsy, although the mechanisms which mediate this effect are not established. The clinical evidence supporting this is derived from patient's… read more here.
Keywords: stress; spike wave; stress hormones; seizures gaers ... See more keywords
Adrenal Cushing Syndrome Diagnosed During Pregnancy: Successful Medical Management With Metyrapone
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DOI: 10.1210/jendso/bvaa167
Abstract: Abstract Adrenal Cushing syndrome during pregnancy is rare, and there is limited information on the effect and safety of metyrapone treatment both for mother and fetus. We present a 24-year-old woman diagnosed with adrenal Cushing… read more here.
Keywords: cortisol; metyrapone; pregnancy; adrenal cushing ... See more keywords
Maternal Metyrapone Use During Breastfeeding: Safe for the Breastfed Infant
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DOI: 10.1210/js.2018-00355
Abstract: Abstract Context Metyrapone is an inhibitor of endogenous adrenal corticosteroid synthesis, which has been proven to be a viable option in controlling maternal serum cortisol concentrations during pregnancy. The infant exposure to maternally ingested metyrapone… read more here.
Keywords: metyrapone; metyrapone use; breast milk; maternal metyrapone ... See more keywords
Differences in the spectrum of steroidogenic enzyme inhibition between Osilodrostat and Metyrapone in ACTH-Dependent Cushing Syndrome Patients.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of endocrinology"
DOI: 10.1530/eje-22-0208
Abstract: INTRODUCTION Osilodrostat is a new 11 ß-hydroxylase inhibitor with a mode of action analogue to Metyrapone. The objective of this study was to compare steroidogenic profiles in patients treated by either Osilodrostat or Metyrapone for… read more here.
Keywords: endocrinology; patients treated; osilodrostat metyrapone; acth dependent ... See more keywords