Inhibition of chaperone-mediated autophagy prevents glucotoxicity in the Caenorhabditis elegans mev-1 mutant by activation of the proteasome.
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DOI: 10.1016/j.bbrc.2017.01.043
Abstract: Chronic hyperglycemia is a hallmark of diabetes mellitus and the main cause of diabetes-associated complications. Increased intracellular glucose levels lead to damaged proteins and in consequence disturb cellular proteostasis. As an important contributor to the… read more here.
Keywords: mev mutant; mediated autophagy; glucotoxicity; chaperone mediated ... See more keywords