Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4+ T cells
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Transplantation"
DOI: 10.1111/ajt.16872
Abstract: The statin family of therapeutics is widely used clinically as cholesterol lowering agents, and their effects to target intracellular mevalonate production is a key mechanism of action. In this study, we performed full transcriptomic RNA… read more here.
Keywords: mevalonate metabolism; costimulation; immunoregulatory phenotype; metabolism ... See more keywords
MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-0114
Abstract: Metabolic dysregulation drives tumor initiation in a subset of glioblastomas harboring isocitrate dehydrogenase (IDH) mutations, but metabolic alterations in glioblastomas with wild-type IDH are poorly understood. MYC promotes metabolic reprogramming in cancer, but targeting MYC… read more here.
Keywords: metabolism; tumor initiating; initiating cells; mevalonate metabolism ... See more keywords
Glucose restriction drives spatial reorganization of mevalonate metabolism
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DOI: 10.7554/elife.62591
Abstract: Eukaryotes compartmentalize metabolic pathways into sub-cellular domains, but the role of inter-organelle contacts in organizing metabolic reactions remains poorly understood. Here, we show that in response to acute glucose restriction (AGR) yeast undergo metabolic remodeling… read more here.
Keywords: mevalonate metabolism; glucose restriction; mevalonate pathway;