PCSK9 Inhibitors, Statins, Low-Density Lipoprotein Cholesterol, Mevalonate Pathway, and Toxicity.
Sign Up to like & getrecommendations! Published in 2017 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2017.2727
Abstract: PCSK9 Inhibitors, Statins, Low-Density Lipoprotein Cholesterol, Mevalonate Pathway, and Toxicity To the Editor In a study by Koren et al,1 proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors exhibited potent and persistent long-term efficacy in reducing… read more here.
Keywords: pcsk9 inhibitors; ldl cholesterol; mevalonate pathway; cholesterol ... See more keywords
The balance between induction and inhibition of mevalonate pathway regulates cancer suppression by statins: A review of molecular mechanisms.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.06.026
Abstract: Statins are widely used drugs for their role in decreasing cholesterol in hypercholesterolemic patients. Statins through inhibition of Hydroxy Methyl Glutaryl-CoA Reductase (HMGCR), the main enzyme of the cholesterol biosynthesis pathway, inhibit mevalonate pathway that… read more here.
Keywords: cancer developing; inhibition mevalonate; mevalonate pathway; mevalonate isoprenoid ... See more keywords
Applying asymptotic methods to synthetic biology: Modelling the reaction kinetics of the mevalonate pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Theoretical Biology"
DOI: 10.1016/j.jtbi.2017.11.022
Abstract: Highlights • We investigate a kinetic model for the mevalonate pathway which includes inhibition effects and a sink of acetyl-CoA.• Of the enzymes in the pathway, upregulating HMG-CoA reductase has the most significant positive effect… read more here.
Keywords: applying asymptotic; hmg coa; mevalonate pathway; biology ... See more keywords
Regulation of endoplasmic reticulum stress and trophectoderm lineage specification by the mevalonate pathway in the mouse preimplantation embryo.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaab015
Abstract: Early embryos are vulnerable to environmental insults, such as medications taken by the mother. Due to increasing prevalence of hypercholesterolemia, more women of childbearing potential are taking cholesterol-lowering medications called statins. Previously, we showed that… read more here.
Keywords: mevalonate pathway; stress; specification; lineage specification ... See more keywords
Inhibition of mevalonate pathway prevents ischemia‐induced cardiac dysfunction in rats via RhoA‐independent signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Therapeutics"
DOI: 10.1111/1755-5922.12285
Abstract: AIM We previously demonstrated that anoxia-mediated Ca2+ handling dysfunction could be ameliorated through inhibition of mevalonate pathway via RhoA- and Ras-related mechanisms in H9c2 cells. In this study, we further explored whether inhibition of mevalonate… read more here.
Keywords: mevalonate pathway; dysfunction; cardiac dysfunction; inhibition mevalonate ... See more keywords
Reconstruction of the “Archaeal” Mevalonate Pathway from the Methanogenic Archaeon Methanosarcina mazei in Escherichia coli Cells
Sign Up to like & getrecommendations! Published in 2020 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.02889-19
Abstract: Two enzymes that have recently been identified from the hyperthermophilic archaeon A. pernix as components of the archaeal mevalonate pathway do not require ATP for their reactions. This pathway, therefore, might consume less energy than… read more here.
Keywords: hyperthermophilic archaeon; archaeal mevalonate; pathway; mevalonate pathway ... See more keywords
The Nonmevalonate Pathway of Isoprenoid Biosynthesis Supports Anaerobic Growth of Listeria monocytogenes
Sign Up to like & getrecommendations! Published in 2019 at "Infection and Immunity"
DOI: 10.1128/iai.00788-19
Abstract: Isoprenoids are an essential and diverse class of molecules, present in all forms of life, that are synthesized from an essential common precursor derived from either the mevalonate pathway or the nonmevalonate pathway. Most bacteria… read more here.
Keywords: growth; listeria monocytogenes; mevalonate pathway; nonmevalonate pathway ... See more keywords
Caffeine supplementation and FOXM1 inhibition enhance the antitumor effect of statins in neuroblastoma.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-3450
Abstract: High-risk neuroblastoma exhibits transcriptional activation of the mevalonate pathway that produces cholesterol and non-sterol isoprenoids. A better understanding of how this metabolic reprogramming contributes to neuroblastoma development could help identify potential prevention and treatment strategies.… read more here.
Keywords: foxm1 inhibition; caffeine; mevalonate pathway;
Abstract 3675: Targeting the mevalonate pathway, a novel anti-ferroptosis pathway, in hepatocellular carcinoma (HCC) treatment
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3675
Abstract: Ferroptosis is a novel immunogenic and regulated cell death caused by iron-dependent lipid peroxidation. Glutathione peroxidase 4(GPX4)/glutathione and ferroptosis suppressor protein 1(FSP1)/Coenzyme Q10(CoQ10) are two major anti-ferroptosis systems that prevent lipid ROS-induced cell death. Our… read more here.
Keywords: ferroptosis; hcc; mevalonate pathway; treatment ... See more keywords
Anti-tumor effects of mevalonate pathway inhibition in ovarian cancer
Sign Up to like & getrecommendations! Published in 2020 at "BMC Cancer"
DOI: 10.1186/s12885-020-07164-x
Abstract: Background Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the onset of chemo-resistance.… read more here.
Keywords: zoledronic acid; mevalonate pathway; ovarian cancer; cancer ... See more keywords
Aβ inhibits SREBP-2 activation through Akt inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m076703
Abstract: We previously demonstrated that oligomeric amyloid β42 (oAβ42) inhibits the mevalonate pathway impairing cholesterol synthesis and protein prenylation. Enzymes of the mevalonate pathway are regulated by the transcription factor SREBP-2. Here, we show that in… read more here.
Keywords: akt; mevalonate pathway; inhibition; srebp activation ... See more keywords