Interplay between MexAB-OprM and MexEF-OprN in clinical isolates of Pseudomonas aeruginosa
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DOI: 10.1038/s41598-018-34694-z
Abstract: MexAB-OprM and MexEF-OprN are Pseudomonas aeruginosa efflux pumps involved in the development of antibiotic resistance. Several studies developed with laboratory strains or using a few clinical isolates have reported that the regulation system of MexEF-OprN… read more here.
Keywords: mexab oprm; interplay; clinical isolates; mexef oprn ... See more keywords
Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02445-17
Abstract: ABSTRACT When overproduced, the multidrug efflux system MexEF-OprN increases the resistance of Pseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory gene mexT result in oligomerization… read more here.
Keywords: pseudomonas aeruginosa; activation mext; constitutive activation; clinical isolates ... See more keywords