False-positive amphetamine results on several drug screening platforms due to mexiletine.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2018.05.013
Abstract: OBJECTIVE False-positive urine drug of abuse screening (UDS) results can have serious implications in clinical practice, particularly when confirmation assay results are not immediately available to providers making medical decisions. Often it is not possible… read more here.
Keywords: amphetamine results; amphetamine; drug; false positive ... See more keywords
Inhibition of cardiac Kv4.3 (Ito) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173159
Abstract: Transient outward K+ current, Ito, contributes to cardiac action potential generation and is primarily carried by Kv4.3 (KCND3) channels. Two Kv4.3 isoforms are expressed in human ventricle and show differential remodeling in heart failure (HF).… read more here.
Keywords: lidocaine mexiletine; kv4 isoforms; mexiletine; antiarrhythmic drugs ... See more keywords
In Situ Derivatization of (RS)-Mexiletine and Enantioseparation Using Micellar Liquid Chromatography: A Green Approach
Sign Up to like & getrecommendations! Published in 2018 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.8b01869
Abstract: Developing surfactant-based aqueous solvents as alternatives to organic solvents for chromatographic enantioseparation is highly desired. Surfactants are inexpensive, nontoxic, environmental friendly, and increase the solubility of organic compounds in aqueous solutions. In this work, the… read more here.
Keywords: enantioseparation; green approach; mexiletine; situ derivatization ... See more keywords
Characterisation of mexiletine’s translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65190-y
Abstract: The ‘translational therapeutic index’ (TTI) is a drug’s ratio of nonclinical threshold dose (or concentration) for significant benefit versus threshold for adversity. In early nonclinical research, discovery and safety studies are normally undertaken separately. Our… read more here.
Keywords: index; translational therapeutic; ischaemia induced; mexiletine ... See more keywords
A case report: Is mexiletine usage effective in the shortening of QTC interval and improving the T‐wave alternans in Timothy syndrome?
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Noninvasive Electrocardiology"
DOI: 10.1111/anec.12522
Abstract: Timothy syndrome (TS) is a multisystemic disease that occurs because of a mutation in CACN1C gene and is characterized by prolonged QT interval. Mexiletine is a Class 1B antiarrhythmic drug that causes the disappearance of… read more here.
Keywords: timothy syndrome; wave alternans; shortening qtc; case ... See more keywords
Thromboelastographic assessment of the impact of mexiletine on coagulation abnormalities induced by air or normal saline intravenous injections in conscious rats.
Sign Up to like & getrecommendations! Published in 2017 at "Diving and hyperbaric medicine"
DOI: 10.28920/dhm47.4.228-232
Abstract: BACKGROUND Thromboelastography (TEG) in venous air embolism (VAE) has been poorly studied. We induced coagulation abnormalities by VAE in a rat model, assessed by TEG with and without mexiletine, a lidocaine analogue local anesthetic. METHODS… read more here.
Keywords: coagulation abnormalities; group; air; normal saline ... See more keywords
Efficacy and tolerability of mexiletine treatment in patients with recurrent ventricular tachyarrhythmias and implantable cardioverter-defibrillator shocks.
Sign Up to like & getrecommendations! Published in 2017 at "Kardiologia polska"
DOI: 10.5603/kp.2017.0189
Abstract: BACKGROUND Antiarrhythmic treatment of patients with recurrent ventricular tachyarrhythmia, in whom catheter ablation and amiodarone treatment were ineffective or contraindicated, is an unsolved clinical problem. AIM The study aims to evaluate the efficacy and tolerability… read more here.
Keywords: tolerability mexiletine; treatment; treatment patients; recurrent ventricular ... See more keywords