Transcriptional coupling (Mfd) and DNA damage scanning (DisA) coordinate excision repair events for efficient Bacillus subtilis spore outgrowth
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DOI: 10.1002/mbo3.593
Abstract: The absence of base excision repair (BER) proteins involved in processing ROS‐promoted genetic insults activates a DNA damage scanning (DisA)‐dependent checkpoint event in outgrowing Bacillus subtilis spores. Here, we report that genetic disabling of transcription‐coupled… read more here.
Keywords: dna damage; mfd; excision repair; repair ... See more keywords
Improvement in cardiometabolic risk markers following a multifunctional diet is associated with gut microbial taxa in healthy overweight and obese subjects
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DOI: 10.1007/s00394-017-1563-3
Abstract: PurposeA multifunctional diet (MFD) targeting subclinical inflammation was developed as a tool to decrease risk factors for cardiometabolic disease in healthy “at-risk” individuals (BMI 25–33 kg/m2). MFD contains several components that are degraded in the colon… read more here.
Keywords: risk markers; risk; mfd; cardiometabolic risk ... See more keywords
Mfd Dynamically Regulates Transcription via a Release and Catch-Up Mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2017.11.017
Abstract: The bacterial Mfd ATPase is increasingly recognized as a general transcription factor that participates in the resolution of transcription conflicts with other processes/roadblocks. This function stems from Mfd's ability to preferentially act on stalled RNA… read more here.
Keywords: catch mechanism; mfd; transcription; release catch ... See more keywords
The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03790-z
Abstract: During transcription elongation, bacterial RNA polymerase (RNAP) can pause, backtrack or stall when transcribing template DNA. Stalled transcription elongation complexes at sites of bulky lesions can be rescued by the transcription terminator Mfd. The molecular… read more here.
Keywords: transcription; mfd; rna polymerase; absence exogenous ... See more keywords
Conjugated linoleic acid (CLA)-induced milk fat depression: application of RNA-Seq technology to elucidate mammary gene regulation in dairy ewes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40881-3
Abstract: Milk fat depression (MFD) is characterized by a reduction in the content of milk fat, presumably caused by the anti-lipogenic effects of rumen biohydrogenation intermediates, such as trans-10 cis-12 conjugated linoleic acid (CLA). In this… read more here.
Keywords: milk; cla; mfd; ewes ... See more keywords
Safety and Short-term Efficacy of a Single Dose of 2 mg Moxidectin in Loa loa–Infected Individuals: A Double-Blind, Randomized Ivermectin-Controlled Trial With Ascending Microfilarial Densities
Sign Up to like & getrecommendations! Published in 2024 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofae240
Abstract: Abstract Background In 2018, the US Food and Drug Administration approved the macrocylic lactone moxidectin (MOX) at 8 mg dosage for onchocerciasis treatment in individuals aged ≥12 years. Severe adverse reactions have occurred after ivermectin (IVM),… read more here.
Keywords: double blind; blind randomized; dose; mfd ... See more keywords
FormulaNet: A Benchmark Dataset for Mathematical Formula Detection
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Access"
DOI: 10.1109/access.2022.3202639
Abstract: One unsolved sub-task of document analysis is mathematical formula detection (MFD). Research by ourselves and others has shown that existing MFD datasets with inline and display formula labels are small and have insufficient labeling quality.… read more here.
Keywords: formulanet; formula; mfd; detection ... See more keywords
Revisiting the Loa loa microfilaremia thresholds above which serious adverse events may occur with ivermectin treatment
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0012957
Abstract: Background Loiasis was long deemed to be a benign condition, but individuals with high Loa loa microfilarial densities (MFD) are at risk of serious adverse events (SAEs) including encephalopathy following ivermectin (IVM) administration. The risk… read more here.
Keywords: age; treatment; mfd; loa loa ... See more keywords
In vitro biohydrogenation of 13C-labeled α-linolenic acid in response to ruminal alterations associated with diet-induced milk fat depression in ewes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dairy science"
DOI: 10.3168/jds.2018-15536
Abstract: The basis for marine lipid-induced milk fat depression (MFD) has not been established yet, but recent reports suggest the putative contribution of shifts in the ruminal metabolism of α-linolenic acid (ALA). To test this hypothesis,… read more here.
Keywords: milk; fat depression; mfd; 13c labeled ... See more keywords
Towards a Holistic Understanding of Musician’s Focal Dystonia: Educational Factors and Mistake Rumination Contribute to the Risk of Developing the Disorder
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychology"
DOI: 10.3389/fpsyg.2022.882966
Abstract: Musicians’ Focal Dystonia (MFD) is a task-specific neurological movement disorder, affecting 1–2% of highly skilled musicians. The condition can impair motor function by creating involuntary movements, predominantly in the upper extremities or the embouchure. The… read more here.
Keywords: mfd; focal dystonia; mistake rumination; disorder ... See more keywords
Accelerated Production of Biopharmaceuticals via Microwave-Assisted Freeze-Drying (MFD)
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15051342
Abstract: Recently, attention has been drawn to microwave-assisted freeze-drying (MFD), as it drastically reduces the typically long drying times of biopharmaceuticals in conventional freeze-drying (CFD). Nevertheless, previously described prototype machines lack important attributes such as in-chamber… read more here.
Keywords: assisted freeze; microwave assisted; mfd; freeze ... See more keywords