MFGE8 protects against CCl4‐induced liver injury by reducing apoptosis and promoting proliferation of hepatocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28314
Abstract: Milk fat globule‐EGF factor 8 (MFGE8) has been reported to play various roles in acute injury and inflammation response. However, the role of MFGE8 in liver injury is poorly investigated. The present research was designed… read more here.
Keywords: induced liver; expression; mfge8; ccl4 induced ... See more keywords
Deciphering the role of MFGE8 in lactation using CRISPR-CAS9 based gene editing in Buffalo mammary epithelial cells
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-00155-7
Abstract: Milk fat globule EGF factor 8 (MFGE8) is a glycoprotein which plays a crucial role in mammary gland remodeling. Our group previously identified MFGE8 as a marker associated with high milk yielding cows. Here, we… read more here.
Keywords: mammary epithelial; role; buffalo mammary; mfge8 ... See more keywords
Liver Wound Healing Is Associated with An Increase in Mfge8 Expression in Hepatocytes
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731962
Abstract: Being recognized as a typical pathological feature of liver diseases, apoptosis-induced hepatocyte injury leading to sterile inflammation drives a wound-healing path in vivo. We and other researchers reported that Milk fat globule-EGF factor 8 (MFGE8)… read more here.
Keywords: wound healing; apoptosis; expression; physiology ... See more keywords
Abstract 4369309: Mfge8/Integrin Signaling in Atherosclerotic Vascular Disease in Diabetes
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4369309
Abstract: Background: Mfge8 is an integrin ligand and a major exosome (EV) protein known to mediate inflammation and atherosclerosis in type 2 diabetes mellitus (T2DM) in animal research. The pathophysiological relevance of this protein in T2DM… read more here.
Keywords: disease; circulating mfge8; vascular disease; protein ... See more keywords
The MFGE8/integrin β3 axis mitigates experimental neutrophilic asthma by suppressing NLRP3-Caspase-1 pathway-mediated NETosis
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DOI: 10.1186/s12931-025-03313-7
Abstract: Neutrophilic asthma, characterized by the relative accumulation of neutrophils in the airways, constitutes a distinct endotype of asthma resistant to corticosteroid and associated with severe and uncontrolled cases. Milk fat globule-EGF factor 8 (MFGE8) is… read more here.
Keywords: integrin; netosis; mfge8; neutrophilic asthma ... See more keywords
Mfge8 Knockout Affects Tail Resorption Speed During Xenopus Metamorphosis.
Sign Up to like & getrecommendations! Published in 2025 at "Zoological science"
DOI: 10.2108/zs250002
Abstract: To elucidate the control mechanism of tail resorption during Xenopus metamorphosis, the expression of mfge8, a macrophage-apoptotic cell bridging molecule that promotes phagocytosis in mammals, was examined. In both Xenopus tropicalis and Xenopus laevis, the… read more here.
Keywords: mfge8; tail resorption; xenopus metamorphosis;