Mitoquinone mitigates paraquat‐induced A549 lung epithelial cell injury by promoting MFN1/MFN2‐mediated mitochondrial fusion
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23127
Abstract: Paraquat (PQ) poisoning often leads to severe lung injuries, in which the mitochondria damage plays a critical role. Mitoquinone (MitoQ), a newly designed mitochondria‐targeted antioxidant, has been proved for its benefit in mitochondria protection. However,… read more here.
Keywords: mitoq; cell; mfn1; lung ... See more keywords
Gemini-based lipoplexes complement the mitochondrial phenotype in MFN1-Knockout mouse embryonic fibroblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00449
Abstract: Mitochondria form a dynamic network of constantly dividing and fusing organelles. The balance between these antagonistic processes is crucial for normal cellular function and requires the action of specialized proteins. The mitochondrial membrane proteins Mitofusin… read more here.
Keywords: phenotype; mfn1; mfn1 knockout; embryonic fibroblasts ... See more keywords
Mitofusin 1-Mediated Redistribution of Mitochondrial Antiviral Signaling Protein Promotes Type 1 Interferon Response in Human Cytomegalovirus Infection
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04615-22
Abstract: Human cytomegalovirus (HCMV) infection is ubiquitous and is often asymptomatic in healthy individuals, but it can cause great damage to newborns, AIDS patients, and other immune deficiency patients. In this study, we found that HCMV… read more here.
Keywords: mfn1; infection; hcmv infection; ifn1 ... See more keywords
Genipin Attenuates Diabetic Cognitive Impairment by Reducing Lipid Accumulation and Promoting Mitochondrial Fusion via FABP4/Mfn1 Signaling in Microglia
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DOI: 10.3390/antiox12010074
Abstract: The present study was conducted to evaluate the effect of genipin (GEN) on the microglia of diabetic cognitive impairment and explore its potential mechanism. Diabetic mice were induced by STZ/HFD, while GEN was intragastrically and… read more here.
Keywords: mfn1; lipid accumulation; diabetic cognitive; cognitive impairment ... See more keywords