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   Articles with "mfn2" as a keyword



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MFN2 deficiency affects calcium homeostasis in lung adenocarcinoma cells via downregulation of UCP4.

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recommendations! Published in 2023 at "FEBS open bio"

DOI: 10.1002/2211-5463.13591

Abstract: Mitofusin‐2 (MFN2) is a transmembrane GTPase that regulates mitochondrial fusion and thereby modulates mitochondrial function. However, the role of MFN2 in lung adenocarcinoma remains controversial. Here, we investigated the effect of MFN2 regulation on mitochondria… read more here.

Keywords: mfn2; mfn2 ucp4; lung adenocarcinoma; calcium homeostasis ... See more keywords

Nationwide Characterization of MFN2-Related CMT in 176 Japanese Patients: Clinical and Genetic Insights.

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recommendations! Published in 2025 at "Annals of clinical and translational neurology"

DOI: 10.1002/acn3.70218

Abstract: Mitofusin 2 (MFN2) is a major causative gene for axonal Charcot – Marie – Tooth disease type 2A (CMT2A), with a wide phenotypic spectrum. Comprehensive large ‐ scale genotype – phenotype association studies are essential… read more here.

Keywords: characterization mfn2; nationwide characterization; mfn2 related; mfn2 ... See more keywords

Repeated Ketamine Anesthesia during the Neonatal Period Impairs Hippocampal Neurogenesis and Long-Term Neurocognitive Function by Inhibiting Mfn2-Mediated Mitochondrial Fusion in Neural Stem Cells

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recommendations! Published in 2024 at "Molecular Neurobiology"

DOI: 10.1007/s12035-024-03921-2

Abstract: The mechanism of ketamine-induced neurotoxicity development remains elusive. Mitochondrial fusion/fission dynamics play a critical role in regulating neurogenesis. Therefore, this study was aimed to evaluate whether mitochondrial dynamics were involved in ketamine-induced impairment of neurogenesis… read more here.

Keywords: long term; mfn2; mitochondrial fusion; ketamine ... See more keywords

Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis.

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recommendations! Published in 2020 at "Environmental research"

DOI: 10.1016/j.envres.2020.109824

Abstract: Exposure to arsenic is a risk factor for nonalcoholic steatohepatitis (NASH). Ferroptosis is a form of regulated cell death defined by the accumulation of lipid peroxidation. In the current study, we observed the occurrence of… read more here.

Keywords: mfn2; nonalcoholic steatohepatitis; ferroptosis; arsenic induced ... See more keywords

MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis.

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recommendations! Published in 2020 at "Osteoarthritis and cartilage"

DOI: 10.1016/j.joca.2019.11.011

Abstract: OBJECTIVE Metabolic disorders and inflammation of chondrocytes are major pathological changes in aging cells and osteoarthritis (OA). Recent studies demonstrated age-related mitochondrial dysfunction may be a key contributing factor in the development of OA. Mitofusin… read more here.

Keywords: mfn2; mfn2 contributes; metabolic disorders; rat chondrocytes ... See more keywords

Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis.

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recommendations! Published in 2022 at "Kidney international"

DOI: 10.1016/j.kint.2022.01.030

Abstract: Macrophages exert critical functions during kidney injury, inflammation, and tissue repair or fibrosis. Mitochondrial structural and functional aberrations due to an imbalance in mitochondrial fusion/fission processes are implicated in the pathogenesis of chronic kidney disease.… read more here.

Keywords: mfn2; kidney fibrosis; mitofusin; macrophage ... See more keywords
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Nagarse treatment of cardiac subsarcolemmal and interfibrillar mitochondria leads to artefacts in mitochondrial protein quantification.

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recommendations! Published in 2018 at "Journal of pharmacological and toxicological methods"

DOI: 10.1016/j.vascn.2018.01.004

Abstract: INTRODUCTION In the heart, subsarcolemmal (SSM), interfibrillar (IFM) and perinuclear mitochondria represent three subtypes of mitochondria. The most commonly used protease during IFM isolation is the nagarse, however, its effect on the detection of mitochondrial… read more here.

Keywords: ssm ifm; mfn2; ifm; mitochondrial proteins ... See more keywords
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Associations between OPA1, MFN1, and MFN2 polymorphisms and primary open angle glaucoma in Polish participants of European ancestry.

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recommendations! Published in 2021 at "Ophthalmic genetics"

DOI: 10.1080/13816810.2021.1970197

Abstract: BACKGROUND Glaucomatous optic nerve damage is caused by selective death of retinal ganglion cells (RGCs). Another condition with underlying loss of RGCs is autosomal dominant optic atrophy (ADOA). Majority of ADOA patients have mutations in… read more here.

Keywords: mfn2; glaucoma; opa1 mfn1; glaucoma polish ... See more keywords

MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission

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recommendations! Published in 2024 at "Acta Physiologica"

DOI: 10.1111/apha.14119

Abstract: Sarcopenia, the aging‐related loss of muscle mass and function, is a debilitating process negatively impacting the quality of life of affected individuals. Although the mechanisms underlying sarcopenia are incompletely understood, impairments in mitochondrial dynamics, including… read more here.

Keywords: young old; mfn2 overexpression; muscles young; overexpression skeletal ... See more keywords

Mitofusin2, a rising star in acute‐on‐chronic liver failure, triggers macroautophagy via the mTOR signalling pathway

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recommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.14658

Abstract: Acute‐on‐chronic liver failure (ACLF) is a life‐threatening syndrome with poor prognosis. Several studies have begun to prove that mitochondria play a crucial role in liver failure. Mitofusin2 (Mfn2) plays a key role in maintaining the… read more here.

Keywords: mfn2; liver failure; liver; mtor ... See more keywords

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A

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recommendations! Published in 2018 at "Science"

DOI: 10.1126/science.aao1785

Abstract: An innovative approach for a rare disease Charcot-Marie-Tooth disease type 2A (CMT2A) is a rare, inherited neurodegenerative condition. Affected individuals develop severe progressive muscle weakness, motor deficits, and peripheral neuropathy. Although defects in the gene… read more here.

Keywords: mfn2; disease; charcot marie; marie tooth ... See more keywords