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   Articles with "mfn2" as a keyword



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MFN2 deficiency affects calcium homeostasis in lung adenocarcinoma cells via downregulation of UCP4.

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recommendations! Published in 2023 at "FEBS open bio"

DOI: 10.1002/2211-5463.13591

Abstract: Mitofusin‐2 (MFN2) is a transmembrane GTPase that regulates mitochondrial fusion and thereby modulates mitochondrial function. However, the role of MFN2 in lung adenocarcinoma remains controversial. Here, we investigated the effect of MFN2 regulation on mitochondria… read more here.

Keywords: mfn2; mfn2 ucp4; lung adenocarcinoma; calcium homeostasis ... See more keywords
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Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis.

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recommendations! Published in 2020 at "Environmental research"

DOI: 10.1016/j.envres.2020.109824

Abstract: Exposure to arsenic is a risk factor for nonalcoholic steatohepatitis (NASH). Ferroptosis is a form of regulated cell death defined by the accumulation of lipid peroxidation. In the current study, we observed the occurrence of… read more here.

Keywords: mfn2; nonalcoholic steatohepatitis; ferroptosis; arsenic induced ... See more keywords
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MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis.

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recommendations! Published in 2020 at "Osteoarthritis and cartilage"

DOI: 10.1016/j.joca.2019.11.011

Abstract: OBJECTIVE Metabolic disorders and inflammation of chondrocytes are major pathological changes in aging cells and osteoarthritis (OA). Recent studies demonstrated age-related mitochondrial dysfunction may be a key contributing factor in the development of OA. Mitofusin… read more here.

Keywords: mfn2; mfn2 contributes; metabolic disorders; rat chondrocytes ... See more keywords
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Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis.

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recommendations! Published in 2022 at "Kidney international"

DOI: 10.1016/j.kint.2022.01.030

Abstract: Macrophages exert critical functions during kidney injury, inflammation, and tissue repair or fibrosis. Mitochondrial structural and functional aberrations due to an imbalance in mitochondrial fusion/fission processes are implicated in the pathogenesis of chronic kidney disease.… read more here.

Keywords: mfn2; kidney fibrosis; mitofusin; macrophage ... See more keywords
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Nagarse treatment of cardiac subsarcolemmal and interfibrillar mitochondria leads to artefacts in mitochondrial protein quantification.

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recommendations! Published in 2018 at "Journal of pharmacological and toxicological methods"

DOI: 10.1016/j.vascn.2018.01.004

Abstract: INTRODUCTION In the heart, subsarcolemmal (SSM), interfibrillar (IFM) and perinuclear mitochondria represent three subtypes of mitochondria. The most commonly used protease during IFM isolation is the nagarse, however, its effect on the detection of mitochondrial… read more here.

Keywords: ssm ifm; mfn2; ifm; mitochondrial proteins ... See more keywords
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Associations between OPA1, MFN1, and MFN2 polymorphisms and primary open angle glaucoma in Polish participants of European ancestry.

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recommendations! Published in 2021 at "Ophthalmic genetics"

DOI: 10.1080/13816810.2021.1970197

Abstract: BACKGROUND Glaucomatous optic nerve damage is caused by selective death of retinal ganglion cells (RGCs). Another condition with underlying loss of RGCs is autosomal dominant optic atrophy (ADOA). Majority of ADOA patients have mutations in… read more here.

Keywords: mfn2; glaucoma; opa1 mfn1; glaucoma polish ... See more keywords
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Mitofusin2, a rising star in acute‐on‐chronic liver failure, triggers macroautophagy via the mTOR signalling pathway

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recommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.14658

Abstract: Acute‐on‐chronic liver failure (ACLF) is a life‐threatening syndrome with poor prognosis. Several studies have begun to prove that mitochondria play a crucial role in liver failure. Mitofusin2 (Mfn2) plays a key role in maintaining the… read more here.

Keywords: mfn2; liver failure; liver; mtor ... See more keywords
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MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A

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recommendations! Published in 2018 at "Science"

DOI: 10.1126/science.aao1785

Abstract: An innovative approach for a rare disease Charcot-Marie-Tooth disease type 2A (CMT2A) is a rare, inherited neurodegenerative condition. Affected individuals develop severe progressive muscle weakness, motor deficits, and peripheral neuropathy. Although defects in the gene… read more here.

Keywords: mfn2; disease; charcot marie; marie tooth ... See more keywords
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Role of tyrosine phosphorylation of Mfn2 in endoplasmic reticulum-mitochondria coupling

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5733327

Abstract: Introduction: A mitochondrial fusion protein, Mitofusin 2 (Mfn2) serves as one of the major components for tethering the mitochondria and endoplasmic reticulum (ER), which regulates the exchange of lipids, Ca2+, and reactive oxygen species (ROS)… read more here.

Keywords: endoplasmic reticulum; mfn2; tyr; microscopy ... See more keywords
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Mitofusin-2 Restrains Hepatic Stellate Cells' Proliferation via PI3K/Akt Signaling Pathway and Inhibits Liver Fibrosis in Rats

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recommendations! Published in 2022 at "Journal of Healthcare Engineering"

DOI: 10.1155/2022/6731335

Abstract: The mitochondrial GTPase mitofusin-2 (MFN2) gene can suppress the cell cycle and regulate cell proliferation in a number of cell types. However, its function in hepatic fibrosis remains largely unexplored. We attempted to understand the… read more here.

Keywords: mfn2; hepatic fibrosis; proliferation; cell ... See more keywords
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The role of Mfn2 in the structure and function of ER-mitochondrial tethering in vivo.

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recommendations! Published in 2021 at "Journal of cell science"

DOI: 10.1242/jcs.253443

Abstract: The mitochondria-ER contacts (MERCs) plays an essential role in multiple cell physiological process. While Mfn2 was the first protein implicated in the formation of MERCs, it is debated whether it acts as a tether or… read more here.

Keywords: mfn2; mfn2 structure; close contacts; mitochondrial tethering ... See more keywords