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Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13591
Abstract: Mitofusin‐2 (MFN2) is a transmembrane GTPase that regulates mitochondrial fusion and thereby modulates mitochondrial function. However, the role of MFN2 in lung adenocarcinoma remains controversial. Here, we investigated the effect of MFN2 regulation on mitochondria…
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Keywords:
mfn2;
mfn2 ucp4;
lung adenocarcinoma;
calcium homeostasis ... See more keywords
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Published in 2020 at "Environmental research"
DOI: 10.1016/j.envres.2020.109824
Abstract: Exposure to arsenic is a risk factor for nonalcoholic steatohepatitis (NASH). Ferroptosis is a form of regulated cell death defined by the accumulation of lipid peroxidation. In the current study, we observed the occurrence of…
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Keywords:
mfn2;
nonalcoholic steatohepatitis;
ferroptosis;
arsenic induced ... See more keywords
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Published in 2020 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2019.11.011
Abstract: OBJECTIVE Metabolic disorders and inflammation of chondrocytes are major pathological changes in aging cells and osteoarthritis (OA). Recent studies demonstrated age-related mitochondrial dysfunction may be a key contributing factor in the development of OA. Mitofusin…
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Keywords:
mfn2;
mfn2 contributes;
metabolic disorders;
rat chondrocytes ... See more keywords
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Published in 2022 at "Kidney international"
DOI: 10.1016/j.kint.2022.01.030
Abstract: Macrophages exert critical functions during kidney injury, inflammation, and tissue repair or fibrosis. Mitochondrial structural and functional aberrations due to an imbalance in mitochondrial fusion/fission processes are implicated in the pathogenesis of chronic kidney disease.…
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Keywords:
mfn2;
kidney fibrosis;
mitofusin;
macrophage ... See more keywords
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Published in 2018 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2018.01.004
Abstract: INTRODUCTION In the heart, subsarcolemmal (SSM), interfibrillar (IFM) and perinuclear mitochondria represent three subtypes of mitochondria. The most commonly used protease during IFM isolation is the nagarse, however, its effect on the detection of mitochondrial…
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Keywords:
ssm ifm;
mfn2;
ifm;
mitochondrial proteins ... See more keywords
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Published in 2021 at "Ophthalmic genetics"
DOI: 10.1080/13816810.2021.1970197
Abstract: BACKGROUND Glaucomatous optic nerve damage is caused by selective death of retinal ganglion cells (RGCs). Another condition with underlying loss of RGCs is autosomal dominant optic atrophy (ADOA). Majority of ADOA patients have mutations in…
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Keywords:
mfn2;
glaucoma;
opa1 mfn1;
glaucoma polish ... See more keywords
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Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14658
Abstract: Acute‐on‐chronic liver failure (ACLF) is a life‐threatening syndrome with poor prognosis. Several studies have begun to prove that mitochondria play a crucial role in liver failure. Mitofusin2 (Mfn2) plays a key role in maintaining the…
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Keywords:
mfn2;
liver failure;
liver;
mtor ... See more keywords
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Published in 2018 at "Science"
DOI: 10.1126/science.aao1785
Abstract: An innovative approach for a rare disease Charcot-Marie-Tooth disease type 2A (CMT2A) is a rare, inherited neurodegenerative condition. Affected individuals develop severe progressive muscle weakness, motor deficits, and peripheral neuropathy. Although defects in the gene…
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Keywords:
mfn2;
disease;
charcot marie;
marie tooth ... See more keywords
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2
Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733327
Abstract: Introduction: A mitochondrial fusion protein, Mitofusin 2 (Mfn2) serves as one of the major components for tethering the mitochondria and endoplasmic reticulum (ER), which regulates the exchange of lipids, Ca2+, and reactive oxygen species (ROS)…
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Keywords:
endoplasmic reticulum;
mfn2;
tyr;
microscopy ... See more keywords
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Published in 2022 at "Journal of Healthcare Engineering"
DOI: 10.1155/2022/6731335
Abstract: The mitochondrial GTPase mitofusin-2 (MFN2) gene can suppress the cell cycle and regulate cell proliferation in a number of cell types. However, its function in hepatic fibrosis remains largely unexplored. We attempted to understand the…
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Keywords:
mfn2;
hepatic fibrosis;
proliferation;
cell ... See more keywords
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Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.253443
Abstract: The mitochondria-ER contacts (MERCs) plays an essential role in multiple cell physiological process. While Mfn2 was the first protein implicated in the formation of MERCs, it is debated whether it acts as a tether or…
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Keywords:
mfn2;
mfn2 structure;
close contacts;
mitochondrial tethering ... See more keywords