Preclinical evaluation of candidate “kill or cure” strategies to treat MFN2-related lipodystrophy
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DOI: 10.1186/s10020-025-01314-2
Abstract: The mitofusin 2 (MFN2) R707W mutation causes debilitating human lipodystrophy featuring lower body adipose loss, upper body adipose hyperplasia, and dyslipidaemic insulin resistance. Mechanical complications include airway compromise due to head and neck adipose overgrowth.… read more here.
Keywords: preclinical evaluation; mfn2r707w; mfn2 related; mfn2r707w r707w ... See more keywords