MG53 Inhibits the Progression of Tongue Cancer Cells through Regulating PI3K-AKT Signaling Pathway: Evidence from 3D Cell Culture and Animal Model.
Sign Up to like & getrecommendations! Published in 2019 at "Small"
DOI: 10.1002/smll.201805492
Abstract: MG53 is transcriptionally activated by the IRS-1/PI3K/AKT signal pathway, which is closely related with oncogenesis of several tumors. Here, the role of MG53 in the tumorigenesis of tongue cancer is analyzed in vitro and in… read more here.
Keywords: mg53; tongue cancer; scc25 cells; pi3k akt ... See more keywords
MG53 Negatively Regulates NLRP3 to Inhibit Inflammation Associated with Tissue Injury
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2876
Abstract: MG53 is a member of the tripartite motif family with E3 ubiquitin ligase activity, and plays important roles in cell membrane repair, tissue regeneration and wound healing. We previously showed that topical or systemic administration… read more here.
Keywords: tissue injury; mg53; associated tissue; inflammation ... See more keywords
Mitsugumin 53 Regulates Extracellular Ca2+ Entry and Intracellular CA2+ Release via Orai1 and RyR1 in Skeletal Muscle
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.568
Abstract: Mitsugumin 53 (MG53) participates in the membrane repair of various cells, and skeletal muscle is the major tissue that expresses MG53. Except for the regulatory effects of MG53 on SERCA1a, the role(s) of MG53 in… read more here.
Keywords: skeletal muscle; mg53; muscle; extracellular ca2 ... See more keywords
MG53 protects against contrast-induced acute kidney injury by reducing cell membrane damage and apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0420-8
Abstract: Mitsugumin 53 (MG53) is a tripartite motif family protein that has been reported to attenuate injury via membrane repair in different organs. Contrast-induced acute kidney injury (CI-AKI) is a common complication caused by the administration… read more here.
Keywords: injury; mg53; cell membrane; kidney ... See more keywords
MG53 represses high glucose-induced inflammation and angiogenesis in human retinal endothelial cells by repressing the EGR1/STAT3 axis
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2054426
Abstract: Abstract Background Diabetic retinopathy (DR) is a vascular complication of diabetes mellitus that leads to visual injury and blindness. Both angiogenesis and inflammation play an important role in the pathogenesis of DR. Here we aimed… read more here.
Keywords: endothelial cells; mg53; stat3; egr1 stat3 ... See more keywords
MG53 attenuates nitrogen mustard‐induced acute lung injury
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16917
Abstract: Nitrogen mustard (NM) is an alkylating vesicant that causes severe pulmonary injury. Currently, there are no effective means to counteract vesicant‐induced lung injury. MG53 is a vital component of cell membrane repair and lung protection.… read more here.
Keywords: nitrogen mustard; lung injury; mg53; induced lung ... See more keywords
Abstract 1729: MG53 suppresses the tumor growth via transcriptional inhibiting the expression of KIF11 in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1729
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with limited therapeutic options and a dismal long-term survival. The upregulation of KIF11, a motor protein that regulates cell mitosis, has been associated with the aggressive proliferation… read more here.
Keywords: tumor growth; pancreatic cancer; mg53; expression ... See more keywords
Blocking MG53S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.122.321055
Abstract: Background: As an integral component of cell membrane repair machinery, MG53 (mitsugumin 53) is important for cardioprotection induced by ischemia preconditioning and postconditioning. However, it also impairs insulin signaling via its E3 ligase activity-mediated ubiquitination-dependent… read more here.
Keywords: mg53; injury; phosphorylation; ligase activity ... See more keywords
Cardiac Ischemic Preconditioning Promotes MG53 Secretion Through H2O2-Activated Protein Kinase C-δ Signaling
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circulationaha.119.044998
Abstract: Supplemental Digital Content is available in the text. Background: Ischemic heart disease is the leading cause of morbidity and mortality worldwide. Ischemic preconditioning (IPC) is the most powerful intrinsic protection against cardiac ischemia/reperfusion injury. Previous… read more here.
Keywords: protein kinase; mg53 secretion; injury; mg53 ... See more keywords
MG53 Inhibits Necroptosis Through Ubiquitination-Dependent RIPK1 Degradation for Cardiac Protection Following Ischemia/Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.868632
Abstract: Rationale While reactive oxygen species (ROS) has been recognized as one of the main causes of cardiac injury following myocardial infarction, the clinical application of antioxidants has shown limited effects on protecting hearts against ischemia–reperfusion… read more here.
Keywords: ripk1 degradation; mg53; injury; ros ... See more keywords
Serum MG53/TRIM72 Is Associated With the Presence and Severity of Coronary Artery Disease and Acute Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.617845
Abstract: Background: Mitsugumin 53 or Tripartite motif 72 (MG53/TRIM72), a myokine/cardiokine belonging to the tripartite motif family, can protect the heart from ischemic injury and regulate lipid metabolism in rodents. However, its biological function in humans… read more here.
Keywords: mg53; serum mg53; mg53 trim72; cad ... See more keywords