miR-149 promotes human osteocarcinoma progression via targeting bone morphogenetic protein 9 (BMP9)
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Letters"
DOI: 10.1007/s10529-017-2445-8
Abstract: ObjectivesTo investigate the roles of miR-149 in the progression of human osteosarcoma (OS).ResultsmiR-149 level was upregulated in tissues from OS patients more than in normal subjects. Cell proliferation and apoptosis assays revealed that miR-149 increased… read more here.
Keywords: mg63 cells; mir 149; protein bmp9; bone morphogenetic ... See more keywords
Involvement of bone morphogenetic protein-related pathways in the effect of aucubin on the promotion of osteoblast differentiation in MG63 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2018.02.005
Abstract: Aucubin, an iridoid glycoside found in several plants, such as Eucommia ulmoide and Rehmannia, has various pharmacological effects. Bone formation is a complex process in which osteoblast differentiation plays an important role. This study aimed… read more here.
Keywords: mg63 cells; protein; differentiation; differentiation mg63 ... See more keywords
Melatonin Increases the Sensitivity of Osteosarcoma Cells to Chemotherapy Drug Cisplatin.
Sign Up to like & getrecommendations! Published in 2022 at "Drug research"
DOI: 10.1055/a-1830-8716
Abstract: Chemotherapy, which is one of the common treatments for osteosarcoma (OS), has many side effects and in some cases has low effectiveness due to chemoresistance, hence it is vital to study new therapies for OS.… read more here.
Keywords: increases sensitivity; combination cisplatin; cisplatin; mg63 cells ... See more keywords
Enterococcus faecalis induces necroptosis in human osteoblastic MG63 cells through the RIPK3 / MLKL signalling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International endodontic journal"
DOI: 10.1111/iej.13323
Abstract: AIM To explore the activation of necroptosis triggered by Enterococcus faecalis in human osteoblastic MG63 cells and provide new insights into the pathogenesis of refractory apical periodontitis. METHODOLOGY The viability of MG63 cells exposed to… read more here.
Keywords: mg63 cells; ripk3 mlkl; human osteoblastic; infection ... See more keywords
Enterococcus faecalis OG1RF induces apoptosis in MG63 cells via caspase-3/-8/-9 without activation of caspase-1/GSDMD.
Sign Up to like & getrecommendations! Published in 2021 at "Oral diseases"
DOI: 10.1111/odi.13996
Abstract: OBJECTIVE Regulated cell death is key in the pathogenesis of persistent apical periodontitis. Here, we investigated the mechanisms of regulated cell death in osteoblast-like MG63 cells infected with Enterococcus faecalis OG1RF. MATERIALS AND METHODS MG63… read more here.
Keywords: mg63 cells; enterococcus faecalis; caspase; faecalis og1rf ... See more keywords
Xianling Gubao attenuates high glucose-induced bone metabolism disorder in MG63 osteoblast-like cells
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0276328
Abstract: Diabetes mellitus (DM) patients are prone to osteoporosis, and high glucose (HG) can affect bone metabolism. In the present study, we investigated the protective effects of traditional Chinese herbal formulation Xianling Gubao (XLGB) on HG-treated… read more here.
Keywords: apoptosis; related proteins; bone; high glucose ... See more keywords
High expression of PKMYT1 predicts poor prognosis and aggravates the progression of osteosarcoma via the NF κB pathway in MG63 cells.
Sign Up to like & getrecommendations! Published in 2023 at "Current cancer drug targets"
DOI: 10.2174/1568009623666230206154944
Abstract: BACKGROUND Protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1) contributes to the proliferative, migratory, invasive and colony forming capabilities of oncocytes. Dysregulated expression of PKMYT1 is associated with numerous malignancies. However, at present, the functional role… read more here.
Keywords: osteosarcoma; pkmyt1; expression; mg63 cells ... See more keywords
Chloroquine Enhances Rapamycin-induced Apoptosis in MG63 Cells
Sign Up to like & getrecommendations! Published in 2019 at "AntiCancer Research"
DOI: 10.21873/anticanres.13159
Abstract: Background/Aim: We previously showed that the use of autophagy inhibitors in combination with chemotherapy can enhance anticancer effects in sarcoma cell lines. In this study, we investigated the combined effect of the autophagy inhibitor chloroquine… read more here.
Keywords: mg63 cells; apoptosis; chloroquine enhances; chloroquine ... See more keywords
Biglycan Interacts with Type I Insulin-like Receptor (IGF-IR) Signaling Pathway to Regulate Osteosarcoma Cell Growth and Response to Chemotherapy
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DOI: 10.3390/cancers14051196
Abstract: Simple Summary Osteosarcoma (OS) is an aggressive, primary bone cancer. OS cells produce altered osteoid whose components participate in signaling correlated to the development of this cancer. Biglycan (BGN), a proteoglycan, is correlated to aggressive… read more here.
Keywords: growth response; igf signaling; growth; receptor ... See more keywords
lncRNA NEAT1 ameliorates LPS-induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2020.4827
Abstract: The mechanisms of inflammation in bone and joint tissue are complex and involve long non-coding RNAs (lncRNAs), which play an important role in this process. The aim of the present study was to screen out… read more here.
Keywords: mg63 cells; neat1 ameliorates; inflammation; inflammation mg63 ... See more keywords
Effect of polygonimitin C on bone formation and resorption in human osteoblast-like MG63 cells
Sign Up to like & getrecommendations! Published in 2017 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v16i7.18
Abstract: Purpose: To investigate the effect of polygonimitin C (PC) on bone formation and resorption in human osteoblast-like MG63 cells. Methods: MG63 cells were treated with PC at doses of 0, 20, 40 or 80 μg/mL… read more here.
Keywords: mg63 cells; bone formation; effect; bone ... See more keywords