LINC00173 promotes Wilms’ tumor progression through MGAT1-mediated MUC3A N-glycosylation
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DOI: 10.1080/15384101.2022.2070399
Abstract: ABSTRACT Recent studies have unveiled that LINC00173 promotes small cell lung cancer progression. However, LINC00173 has not been studied in Wilms’ tumor (WT). N-glycosylation is a complex post-translational protein modification, and alterations of protein glycosylation… read more here.
Keywords: wilms tumor; mgat1; progression; glycosylation ... See more keywords
MicroRNA miR-331-3p suppresses osteosarcoma progression via the Bcl-2/Bax and Wnt/β-Catenin signaling pathways and the epithelial-mesenchymal transition by targeting N-acetylglucosaminyltransferase I (MGAT1)
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DOI: 10.1080/21655979.2022.2083855
Abstract: ABSTRACT Osteosarcoma (OS) is a high-grade malignant disease that is a prevalent primary malignant sarcoma of the bone. The purpose of this investigation was to therefore elucidate the association between miR-331-3p and OS development and… read more here.
Keywords: mgat1; wnt catenin; mir 331; bcl bax ... See more keywords
Abstract P2-06-12: MGAT1-Mediated Glycosylation Orchestrates Immune Checkpoints and Antitumor Immunity
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DOI: 10.1158/1557-3265.sabcs24-p2-06-12
Abstract: Despite the widespread application of immunotherapy, treating immune-cold tumors remains a significant challenge in cancer therapy. Using multiomic spatial analyses and experimental validation, we have identified MGAT1, a glycosyltransferase, as a pivotal factor governing tumor… read more here.
Keywords: cd73; mgat1; cancer; mgat1 mediated ... See more keywords