LAUSR

Substrate Engagement and Catalytic Mechanisms of N-Acetylglucosaminyltransferase V

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0 Published in 2020 at "ACS Catalysis"

DOI: 10.1021/acscatal.0c02222

Abstract: α-Mannoside β-1,6-N-acetylglucos­aminyl­transferase V (MGAT5) is a mammalian glycosyltransferase involved in complex N-glycan formation, which strongly drives cancer when overexpressed. Despite intense interest, the catalytic mechanism of MGAT5 is not known in detail, precluding therapeutic exploitation.… read more here.

Keywords: mgat5; engagement catalytic; catalytic mechanisms; mechanisms acetylglucosaminyltransferase ... See more keywords

IGF2BP1 promotes the liver cancer stem cell phenotype by regulating MGAT5 mRNA stability via m6A RNA methylation.

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1 Published in 2021 at "Stem cells and development"

DOI: 10.1089/scd.2021.0153

Abstract: The aim of this study was to elucidate the mechanism of action of the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) on the phenotype of the liver cancer stem cells (LCSCs). To gain insight… read more here.

Keywords: mgat5; mrna stability; via m6a; stem ... See more keywords

Loss of MGAT5 is involved in the impaired osteogenic differentiation of bone marrow mesenchymal stem cells.

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2 Published in 2023 at "Experimental animals"

DOI: 10.1538/expanim.22-0129

Abstract: The imbalance of bone resorption and bone formation causes osteoporosis (OP), a common skeletal disorder. Decreased osteogenic activity was found in the bone marrow cultures from MGAT5-deficient mice. We hypothesized that MGAT5 was associated with… read more here.

Keywords: bone marrow; bone; mgat5; osteogenic differentiation ... See more keywords