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   Articles with "mgat5" as a keyword



Substrate Engagement and Catalytic Mechanisms of N-Acetylglucosaminyltransferase V

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recommendations! Published in 2020 at "ACS Catalysis"

DOI: 10.1021/acscatal.0c02222

Abstract: α-Mannoside β-1,6-N-acetylglucos­aminyl­transferase V (MGAT5) is a mammalian glycosyltransferase involved in complex N-glycan formation, which strongly drives cancer when overexpressed. Despite intense interest, the catalytic mechanism of MGAT5 is not known in detail, precluding therapeutic exploitation.… read more here.

Keywords: mgat5; engagement catalytic; catalytic mechanisms; mechanisms acetylglucosaminyltransferase ... See more keywords

IGF2BP1 promotes the liver cancer stem cell phenotype by regulating MGAT5 mRNA stability via m6A RNA methylation.

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recommendations! Published in 2021 at "Stem cells and development"

DOI: 10.1089/scd.2021.0153

Abstract: The aim of this study was to elucidate the mechanism of action of the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) on the phenotype of the liver cancer stem cells (LCSCs). To gain insight… read more here.

Keywords: mgat5; mrna stability; via m6a; stem ... See more keywords

Bioinformatics analysis revealing clinical significance of MGAT5 in colon adenocarcinoma

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recommendations! Published in 2025 at "Medicine"

DOI: 10.1097/md.0000000000045578

Abstract: This study investigates the expression and clinical significance of N-acetylglucosaminyltransferase V (MGAT5) in colon adenocarcinoma (COAD) using bioinformatics methods. The mRNA and protein expression of MGAT5 in COAD tissues and the expression of MGAT5 in… read more here.

Keywords: mgat5 colon; clinical significance; coad; expression ... See more keywords

N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation

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recommendations! Published in 2024 at "Cancer Cell International"

DOI: 10.1186/s12935-024-03551-7

Abstract: Increasing evidence supports the crucial role of Epithelial-Mesenchymal Transition (EMT) in cancer invasion and metastasis. N-acetylglucosaminyltransferase V (MGAT5), which is associated with multiantenna glycosylation, can contribute to tumorigenesis, yet its specific role in promoting colorectal… read more here.

Keywords: colorectal cancer; cancer; ubiquitination degradation; acetylglucosaminyltransferase ... See more keywords

Loss of MGAT5 is involved in the impaired osteogenic differentiation of bone marrow mesenchymal stem cells.

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recommendations! Published in 2023 at "Experimental animals"

DOI: 10.1538/expanim.22-0129

Abstract: The imbalance of bone resorption and bone formation causes osteoporosis (OP), a common skeletal disorder. Decreased osteogenic activity was found in the bone marrow cultures from MGAT5-deficient mice. We hypothesized that MGAT5 was associated with… read more here.

Keywords: bone marrow; bone; mgat5; osteogenic differentiation ... See more keywords