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Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2268-8
Abstract: Tetrandrine (Tet) is a macrocyclic tetrahydroisoquinoline alkaloid isolated from Stephania tetrandra S. Moore along with other Chinese and Japanese herbs. It has been used extensively for the treatment of silicosis, autoimmune disorders, inflammatory diseases and…
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Keywords:
mgc 803;
gastric cancer;
tetrandrine;
tet ... See more keywords
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Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113108
Abstract: In this work, we reported the discovery of compound 6i with potent antiproliferative activity against MGC-803. Among these compounds, the most potent compound 6i could effectively inhibit MGC-803 (IC50 = 0.96 μM), being around 38-fold selectivity over GES-1.…
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Keywords:
mgc 803;
discovery triazolo;
triazolo pyrimidines;
derivatives potential ... See more keywords
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Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.145044
Abstract: OBJECTIVE Gastric cancer is the most common malignant tumor. Most patients suffering from gastric cancer die of metastasis. The role of Atrial natriuretic peptide (ANP) in inhibiting and eliminating kinds of cancer cells has been…
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Keywords:
anp;
hedgehog signaling;
mgc 803;
gastric cancer ... See more keywords
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Published in 2018 at "MedChemComm"
DOI: 10.1039/c7md00428a
Abstract: A novel nickel(ii) complex of 6-methoxy-1-pyridine-β-carboline (4a) was synthesized and characterized. The cytotoxicities of the complex towards six cancer cell lines, including MGC-803, Hep G2, T24, OS-RC-2, NCI-H460, and SK-OV-3, and human normal liver cell…
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Keywords:
mgc 803;
nickel complex;
based nickel;
derivative based ... See more keywords
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Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/c9nj05846j
Abstract: Twenty-seven 3-(benzo[d]thiazol-2-yl)-4-aminoquinoline derivatives have been designed and synthesized as topoisomerase I inhibitors. The in vitro anti-proliferation evaluation against four human cancer cell lines (MGC-803, HepG-2, T24, and NCI-H460) and one normal cell line (HL-7702) indicated…
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Keywords:
thiazol aminoquinoline;
mgc 803;
dna;
benzo thiazol ... See more keywords
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Published in 2019 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2019.1597056
Abstract: Abstract Amino acid derivatives containing chrysin were synthesized for evaluating their anticancer effects. Among them, compound N-(7-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)heptanoyl)-L-isoleucine (6e) displayed the most potent antiproliferative activity against MGC-803 cells with IC50 value of 20.0 μM. Preliminary mechanistic studies…
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Keywords:
amino acid;
mgc 803;
acid derivatives;
cell ... See more keywords
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Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.646628
Abstract: Galangin, a flavonoid isolated from the rhizome of Alpinia officinarum (Hance), exerts anticancer activities against many cancer cells such as liver cancer, breast cancer, lung cancer and esophageal cancer. However, the effect, as well as…
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Keywords:
mgc 803;
gastric cancer;
stat3;
galangin ... See more keywords
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Published in 2020 at "Molecules"
DOI: 10.3390/molecules25235530
Abstract: Chalcone is a common scaffold found in many biologically active compounds. The chalcone scaffold was also frequently utilized to design novel anticancer agents with potent biological efficacy. Aiming to continue the research of effective chalcone…
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Keywords:
mgc 803;
chalcone derivatives;
compound 13e;
amino chalcone ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154996
Abstract: [1,2,4]Triazolo[1,5-a]pyrimidine and indole skeletons are widely used to design anticancer agents. Therefore, in this work, a series of [1,2,4]triazolo[1,5-a]pyrimidine indole derivatives were designed and synthesized by the molecular hybridization strategy. The antiproliferative activities of the…
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Keywords:
erk signaling;
pyrimidine indole;
triazolo pyrimidine;
signaling pathway ... See more keywords
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Published in 2017 at "Oncology reports"
DOI: 10.3892/or.2017.6028
Abstract: Curcumol, a polyphenol compound derived from the rhizome of Curcuma, has been established as an antitumor compound against multiple types of cancer, including gastric (GC), lung, liver and breast cancer. However, the molecular mechanisms undelying its…
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Keywords:
curcumol;
adenocarcinoma mgc;
mgc 803;
gastric adenocarcinoma ... See more keywords