SAT-347-MRI-PDFF response in MGL-3196 and placebo treated patients predicts reduction in ballooning and inflammation components of NAS and NASH resolution in a 36-week serial liver biopsy study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Hepatology"
DOI: 10.1016/s0618-8278(19)31577-4
Abstract: MRI-PDFF response in MGL-3196 and placebo treated patients predicts reduction in ballooning and inflammation components of NAS and NASH resolution in a 36-week serial liver biopsy study Stephen Harrison1, Cynthia Guy2, Rebecca Taub3, Mustafa Bashir2… read more here.
Keywords: pdff response; 3196 placebo; mri pdff; mgl 3196 ... See more keywords
Cell-Specific Transport and Thyroid Hormone Receptor Isoform Selectivity Account for Hepatocyte-Targeted Thyromimetic Action of MGL-3196
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DOI: 10.3390/ijms232213714
Abstract: Thyroid hormones (THs) and TH receptor-beta (TRβ) reduce hepatic triglycerides, indicating a therapeutic potential for TH analogs in liver steatosis. To avoid adverse extrahepatic, especially TRα-mediated effects such as tachycardia and bone loss, TH analogs… read more here.
Keywords: mgl 3196; isoform; mgl; thyromimetic action ... See more keywords