Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2016.10.007
Abstract: HIGHLIGHTSSelective ligands have helped define the neurobiological roles of mGlu receptors.Biased agonism/modulation is a key feature of mGlu signaling.Biased signaling should inform future mGlu drug discovery programs. &NA; The metabotropic glutamate (mGlu) receptor family is… read more here.
Keywords: modulation; neurobiological insights; mglu receptor; cns disorders ... See more keywords
Acid‐sensing ion channel 1a is required for mGlu receptor dependent long‐term depression in the hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2017.01.028
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Acid‐sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are widely distributed in the mammalian nervous system. ASIC1a is highly permeable to Ca2+ and are thought… read more here.
Keywords: sensing ion; mglu receptor; receptor; group mglu ... See more keywords