mGlu1 receptor canonical signaling pathway contributes to the opening of the orphan GluD2 receptor
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DOI: 10.1016/j.neuropharm.2016.06.001
Abstract: &NA; The orphan Glutamate receptor Delta2 (GluD2) intrinsic ion channel activity is indirectly triggered by glutamate through stimulation of the metabotropic glutamate receptor 1 (mGlu1), in cerebellar Purkinje cells. However, the mechanisms of GluD2 ion… read more here.
Keywords: mglu1; canonical signaling; glud2; glud2 channels ... See more keywords
Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration
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DOI: 10.1016/j.neuroscience.2017.09.005
Abstract: Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration. In all these disorders excitotoxicity is a prominent component of… read more here.
Keywords: mglu1 metabotropic; mglu1; metabotropic glutamate; retinal degeneration ... See more keywords