Activation of mGlu2/3 receptors, a novel therapeutic approach to alleviate dyskinesia and psychosis in experimental parkinsonism
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107725
Abstract: Selective blockade of serotonin 2A (5-HT2A) receptors is a promising strategy to reduce L-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia and has shown efficacy in a Phase III clinical trial for dopaminergic psychosis in Parkinson's disease (PD). However, pre-clinical… read more here.
Keywords: mglu2 receptors; activation mglu2; dyskinesia psychosis; mglu2 ... See more keywords
Reinforcing actions through the thalamostriatal circuit
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-00814-5
Abstract: Glutamatergic cortical inputs to the striatum are well-known drivers of striatal activity and play prominent roles in reinforcement learning [1]. Despite longstanding knowledge that thalamic nuclei also contribute anatomically notable glutamatergic inputs to the striatum,… read more here.
Keywords: dopamine release; self stimulation; stimulation; activity ... See more keywords
mGlu2 mechanism-based interventions to treat alcohol relapse
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.985954
Abstract: Recently we identified a deficiency in metabotropic glutamate receptor 2 (mGlu2) function in the corticoaccumbal pathway, as a common pathological mechanism underlying alcohol-seeking and relapse behavior. Based on this mechanism, we hypothesized that mGlu2/3 agonists… read more here.
Keywords: mglu2; mglu2 mechanism; relapse; mglu2 agonist ... See more keywords