Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.04.006
Abstract: Metabotropic glutamate receptor (mGlu)5 regulates microglia activation, which contributes to inflammation. However, the role of mGlu5 in neuroinflammation associated with Parkinson's disease (PD) remains unclear. Triptolide (T10) exerts potent immunosuppressive and anti-inflammatory effects and protects… read more here.
Keywords: mglu5; t10; microglia activation; induced model ... See more keywords
Evaluation of Synthetic Cytochrome P450-Mimetic Metalloporphyrins To Facilitate “Biomimetic” Biotransformation of a Series of mGlu5 Allosteric Ligands
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b02017
Abstract: Allosteric ligands within a given chemotype can have the propensity to display a wide range of pharmacology, as well as unexpected changes in GPCR subtype selectivity, typically mediated by single-atom modifications to the ligand. Due… read more here.
Keywords: mglu5; allosteric ligands; synthetic cytochrome; pharmacology ... See more keywords
Altered Expression and in vivo Activity of mGlu5 variant a Receptors in the striatum of BTBR mice: Novel insights into the pathophysiology of adult idiopathic forms of autism spectrum disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Current neuropharmacology"
DOI: 10.2174/1567202619999220209112609
Abstract: mGlu5 metabotropic glutamate receptors are considered as candidate drug targets in the treatment of "monogenic" forms of autism spectrum disorders (ASD), such as Fragile-X syndrome (FXS). However, despite promising preclinical data, clinical trials using mGlu5… read more here.
Keywords: idiopathic forms; expression; btbr mice; mglu5 ... See more keywords