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   Articles with "mglur" as a keyword



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Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-09382-9

Abstract: Autism spectrum disorder (ASD) is characterized by dysfunction in social interactions, stereotypical behaviours and high co-morbidity with intellectual disability. A variety of syndromic and non-syndromic neurodevelopmental disorders have been connected to alterations in metabotropic glutamate… read more here.

Keywords: mglur; autism; role; synaptic plasticity ... See more keywords
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Small-molecule screening in aged Drosophila identifies mGluR as a regulator of age-related sleep impairment.

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recommendations! Published in 2023 at "Sleep"

DOI: 10.1093/sleep/zsad018

Abstract: As a normal physiological phenomenon, aging has a significant impact on sleep. Aging leads to sleep impairment, including sleep loss, fragmented sleep, and a lower arousal threshold, leading to various diseases. Because sleep regulates memory… read more here.

Keywords: sleep impairment; age dependent; mglur; age ... See more keywords
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The MK2 cascade mediates transient alteration in mGluR‐LTD and spatial learning in a murine model of Alzheimer's disease

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recommendations! Published in 2022 at "Aging Cell"

DOI: 10.1111/acel.13717

Abstract: A key aim of Alzheimer disease research is to develop efficient therapies to prevent and/or delay the irreversible progression of cognitive impairments. Early deficits in long‐term potentiation (LTP) are associated with the accumulation of amyloid… read more here.

Keywords: mglur ltd; mk2 cascade; mglur; alzheimer disease ... See more keywords
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mGluR-dependent plasticity in rodent models of Alzheimer’s disease

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recommendations! Published in 2023 at "Frontiers in Synaptic Neuroscience"

DOI: 10.3389/fnsyn.2023.1123294

Abstract: Long-term potentiation (LTP) and depression (LTD) are currently the most comprehensive models of synaptic plasticity models to subserve learning and memory. In the CA1 region of the hippocampus LTP and LTD can be induced by… read more here.

Keywords: ltp ltd; mglur; alzheimer disease; mglur dependent ... See more keywords