Discovery of 6,7-Dihydropyrazolo[1,5-a]pyrazin-4(5H)-one Derivatives as mGluR2 Negative Allosteric Modulators with In Vivo Activity in a Rodent's Model of Cognition.
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DOI: 10.1021/acs.jmedchem.4c01227
Abstract: Allosteric modulators of the metabotropic group II receptors, mGluR2 and mGluR3, have been widely explored due to their ability to modulate cognitive and neurological functions in mood disorders, although none have been approved yet. In… read more here.
Keywords: allosteric modulators; negative allosteric; dihydropyrazolo pyrazin; mglur2 negative ... See more keywords