Protein kinase Cɛ activity regulates mGluR5 surface expression in the rat nucleus accumbens
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23868
Abstract: Type 5 metabotropic glutamate receptors (mGluR5) activate protein kinase C (PKC) via coupling to Gαq/11 protein signaling. We have previously demonstrated that the epsilon isoform of PKC (PKCɛ) is a critical downstream target of mGluR5… read more here.
Keywords: pkc; mglur5 surface; mglur5; surface expression ... See more keywords
MTEP impedes the neuronal polarization and the activity of the Akt–NF‐κB pathway in rat hippocampal neurons
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24002
Abstract: Metabotropic glutamate receptor 5 (mGluR5) is extensively involved in neural survival, differentiation, dendritic morphology, synaptic plasticity, and neural circuit formation. However, little is known about its role in neuronal polarization and axon outgrowth. In this… read more here.
Keywords: hippocampal neurons; axon outgrowth; mglur5; neuronal polarization ... See more keywords
Metabotropic glutamate receptor 5‐mediated inhibition of inward‐rectifying K+ channel 4.1 contributes to orofacial ectopic mechanical allodynia following inferior alveolar nerve transection in male mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25181
Abstract: Inward‐rectifying K+ channel 4.1 (Kir4.1), which regulates the electrophysiological properties of neurons and glia by affecting K+ homeostasis, plays a critical role in neuropathic pain. Metabotropic glutamate receptor 5 (mGluR5) regulates the expression of Kir4.1… read more here.
Keywords: orofacial ectopic; allodynia; mechanical allodynia; ectopic mechanical ... See more keywords
Differential mGluR5 expression in response to the same stress causes individually adapted hippocampal network activity.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.172
Abstract: Individual differences in stress vulnerability and resilience have been observed even within a single cohort of inbred rats or mice. Stress phenotypes are typically quantified as changes in the behavior of experimental animals, which is… read more here.
Keywords: network; mglur5; mglur5 expression; stress ... See more keywords
Immunohistochemical comparison of astrocytic mGluR5 upregulation in infraorbital nerve- versus sciatic nerve-ligated rat
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.05.035
Abstract: The differential pharmacological responsiveness of cephalic and extra-cephalic neuropathic pain has been proposed to relate to distinct mechanisms that may involve neuroinflammatory reactions mediated by glial cells. Astrocytes are particularly important for neuronal sensitization in… read more here.
Keywords: infraorbital nerve; mglur5; astrocytic mglur5; neuropathic pain ... See more keywords
Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression
Sign Up to like & getrecommendations! Published in 2018 at "Molecular psychiatry"
DOI: 10.1038/mp.2017.58
Abstract: The mechanisms of action of the rapid antidepressant effects of ketamine, an N-methyl-D-aspartate glutamate receptor antagonist, have not been fully elucidated. This study examined the effects of ketamine on ligand binding to a metabotropic glutamatergic… read more here.
Keywords: reduction; mglur5; ketamine induced; mglur5 availability ... See more keywords
Improved retinal function in RCS rats after suppressing the over-activation of mGluR5
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03702-z
Abstract: Müller cells maintain retinal synaptic homeostasis by taking up glutamate from the synaptic cleft and transporting glutamine back to the neurons. To study the interaction between Müller cells and photoreceptors, we injected either DL-α-aminoadipate or… read more here.
Keywords: mglur5; retinal function; activation mglur5; improved retinal ... See more keywords
Excitotoxic neurodegeneration is associated with a focal decrease in metabotropic glutamate receptor type 5 availability: an in vivo PET imaging study
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49356-x
Abstract: Metabotropic glutamate receptors (mGluRs) have been proposed as promising therapeutic targets to correct the dysregulated glutamate signaling, associated with neurodegenerative pathologies. Of all mGluR subtypes, especially mGluR5 acts as a modulator of glutamate-induced excitotoxicity. To… read more here.
Keywords: availability; mglur5; metabotropic glutamate; study ... See more keywords
mGluR5-mediated astrocytes hyperactivity in the anterior cingulate cortex contributes to neuropathic pain in male mice
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-07733-5
Abstract: Astrocytes regulate synaptic transmission in healthy and pathological conditions, but their involvement in modulating synaptic transmission in chronic pain is unknown. Our study demonstrates that astrocytes in the anterior cingulate cortex (ACC) exhibit abnormal calcium… read more here.
Keywords: mice; pain; male mice; mglur5 ... See more keywords
mGluR5 Tunes NGF/TrkA Signaling to Orient Spiny Stellate Neuron Dendrites Toward Thalamocortical Axons During Whisker-Barrel Map Formation
Sign Up to like & getrecommendations! Published in 2018 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhx105
Abstract: Neurons receive and integrate synaptic inputs at their dendrites, thus dendritic patterning shapes neural connectivity and behavior. Aberrant dendritogenesis is present in neurodevelopmental disorders such as Down's syndrome and autism. Abnormal glutamatergic signaling has been… read more here.
Keywords: whisker barrel; barrel map; mglur5; barrel ... See more keywords
Overlapping syndrome of anti-MOG antibody-associated disease and anti-mGluR5 encephalitis manifested as optic neuritis: A case report
Sign Up to like & getrecommendations! Published in 2024 at "Medicine"
DOI: 10.1097/md.0000000000039146
Abstract: Rationale: Anti-Myelin oligodendrocyte glycoprotein (MOG) and anti-metabotropic glutamate receptor 5 (mGluR5) double antibody positive encephalitis characterized by optic neuritis is extremely rare. We present a case of overlapping syndrome of MOG-IgG-associated disease and anti-mGluR5 encephalitis… read more here.
Keywords: encephalitis; antibody; anti; optic neuritis ... See more keywords